2-Methylamino-1-phenylpropan-2-ol hydrochloride

Base Information

• Chemical Name: 2-Methylamino-1-phenylpropan-2-ol hydrochloride
• CAS No.: 24221-86-1
• Deprecated CAS: 77274-98-7
• Molecular Formula: C10H15 N O . Cl H
• Molecular Weight: 201.696
• Hs Code.: 29394100
• European Community (EC) Number: 205-153-9,246-090-7
• UNII: 43SK4LAO7D
• DSSTox Substance ID: DTXSID00889337,DTXSID40947041
• Wikidata: Q27258670
• NCI Thesaurus Code: C81365
• ChEMBL ID: CHEMBL2104837
• Mol file: 24221-86-1.mol

Synonyms:24221-86-1;134-71-4;2-Methylamino-1-phenylpropan-2-ol hydrochloride;D-Ephedrine hydrochloride;(+)-Ephedrine, hydrochloride;(+)-EPHEDRINE HYDROCHLORIDE;EINECS 246-090-7;(1S,2R)-(+)-Ephedrine hydrochloride;43SK4LAO7D;(1S,2R)-2-(methylamino)-1-phenylpropan-1-ol;hydrochloride;Racephedrine HCl;Ephedrine, hydrochloride, (+)-;Racephedrine hydrochloride [USAN];(S-(R*,S*))-alpha-(1-(Methylamino)ethyl)benzenemethanol, hydrochloride;Benzenemethanol, alpha-((1R)-1-(methylamino)ethyl)-, hydrochloride, (alphaS)-;Benzenemethanol, alpha-(1-(methylamino)ethyl)-, hydrochloride, (S-(R*,S*))-;( inverted exclamation markA)-Ephedrine (hydrochloride);Racephedrine Hydrochloride (USAN);Ephedrine, hydrochloride, ()-;Benzenemethanol, alpha-((1R)-1-(methylamino)ethyl)-, hydrochloride (1:1), (alphaS)-;UNII-43SK4LAO7D;Ephedrine dl- hydrochloride;C10H15NO.ClH;Ephedrine dl-form hydrochloride;Ephedrine hydrochloride, racemic;Ephedrine, hydrochloride, (+-)-;(+/-)-2-Ephedrinium Hydrochloride;EC 205-153-9;Benzenemethanol, .alpha.-[1-(methylamino)ethyl]-, hydrochloride, [S-(R*,S*)]-;Benzenemethanol, .alpha.-[1-(methylamino)ethyl]-, hydrochloride,[S-(R*,S*)]-;()-Eperisone hydrochloride;dl-alpha(1-(Methylamino)ethyl)benzyl alcohol hydrochloride;1S,2R(+)-Ephedrine HCl;Ephedrine hydrochloride, 99%;SCHEMBL321655;(R*,S*)-(+-)-alpha-(1-(Methylamino)ethyl)benzyl alcohol hydrochloride;(R*,S*)-(1)-alpha-(1-(Methylamino)ethyl)benzyl alcohol hydrochloride;Benzenemethanol, ?-[1-(methylamino)ethyl]-, hydrochloride, [R-(R,S)]-;CHEMBL2104837;DTXSID00889337;DTXSID40947041;Bencenometanol, Alfa-[(1S)-1-(metilamino) etil]-, clorhidrato (1:1), (Alfa R)-;Benzenemethanol, alpha-((1R)-1-(methylamino)ethyl)-, hydrochloride, (alphaS)-rel-;Benzenemethanol, alpha-(1-(methylamino)ethyl)-, hydrochloride, (theta,S)-(+/-)-;HY-B0980;AKOS027321135;CS-4470;NSC 757308;LS-63971;RACEPHEDRINE HYDROCHLORIDE [MART.];RACEPHEDRINE HYDROCHLORIDE [WHO-DD];EPHEDRINE DL-FORM HYDROCHLORIDE [MI];(1S,2R)-(+)-Ephedrine hydrochloride, 99%;D08982;A806827;Ephedrine hydrochloride (racemic) - Drug Precursor;(+)-Ephedrine hydrochloride, purum, >=99.0% (AT);EPHEDRINE HYDROCHLORIDE, RACEMIC [EP MONOGRAPH];Q27258670;(1S,2R)-2-(methylamino)-1-phenyl-1-propanol hydrochloride;(1S,2R)-2-(methylamino)-1-phenyl-propan-1-ol hydrochloride;(1S,2R)-(+)-Ephedrine Hydrochloride 1.0 mg/ml in Methanol (as free base);Benzenemethanol, alpha-((1R)-1-(methylamino)ethyl)-, hydrochloride (1:1), (alphaS)-rel-;Ephedrine hydrochloride (racemic), European Pharmacopoeia (EP) Reference Standard;(1S,2R)-(+)-Ephedrine hydrochloride, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material

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Chemical Property of 2-Methylamino-1-phenylpropan-2-ol hydrochloride

Chemical Property:

• Appearance/Colour: White crystalline powder.
• Vapor Pressure: 0.00865mmHg at 25°C
• Melting Point: 218-220 ºC
• Boiling Point: 255 °C at 760 mmHg
• Flash Point: 85.6 °C
• PSA: 32.26000
• Density: g/cm³
• LogP: 2.52080
• Storage Temp.: Refrigerator
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 201.0920418
• Heavy Atom Count: 13
• Complexity: 121

Purity/Quality:

Safty Information:

• Hazard Codes: Xn,T,F
• Statements: 22-39/23/24/25-23/24/25-11
• Safety Statements: 22-25-45-36/37-16-7

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(C(C1=CC=CC=C1)O)NC.Cl
• Isomeric SMILES: C[C@H]([C@H](C1=CC=CC=C1)O)NC.Cl

Technology Process of 2-Methylamino-1-phenylpropan-2-ol hydrochloride

There total 2 articles about 2-Methylamino-1-phenylpropan-2-ol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ephedrine (90-81-3,7009-81-6,90-83-5,6912-63-6) → (+)-(1S,2R)-ephedrine hydrochloride (24221-86-1)

Guidance literature:

DOI:10.1246/cl.1981.857

Reference yield:

→ (+)-(1S,2R)-ephedrine hydrochloride (24221-86-1)

Guidance literature:

Reference yield: 99.0%

3-methylphenylsulfonyl chloride (1899-93-0) + (+)-(1S,2R)-ephedrine hydrochloride (24221-86-1) → N-(3-methylbenzenesulfonyl)-(1S,2R)-ephedrine

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/acs.orglett.0c01301

upstream raw materials:

ephedrine

Downstream raw materials:

((1RS,2RS)-2-chloro-1-methyl-2-phenyl-ethyl)-methyl-amine

acetic acid-((1RS,2RS)-2-methylamino-1-phenyl-propylester); hydrochloride

(2S,4S,5R)-2-chloro-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidin-2-one

(2R,4S,5R)-2-chloro-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidin-2-one

Refernces

• 1、 Saigo, Kazuhiko,Okuda, Yoshiyuki,Wakabayashi, Sumio,Hoshiko, Tomonori,Nohira, Hiroyuki. "OPTICAL RESOLUTION OF 3-endo-BENZAMIDO-5-NORBORNENE-2-endo-CARBOXYLIC ACID AND ITS APPLICATION AS A NEW RESOLVING AGENT". . p. 857 - 860. Retrieved 2007/10/02.