bis(4-methoxybenzyl)diselane

Base Information

• Chemical Name: bis(4-methoxybenzyl)diselane
• CAS No.: 62212-22-0
• Molecular Formula: C16H18O2Se2
• Molecular Weight: 400.238
• Mol file: 62212-22-0.mol

Synonyms:Bis(4-methoxybenzyl)diselenide;NSC 297298;

Chemical Property of bis(4-methoxybenzyl)diselane

Chemical Property:

• Vapor Pressure: 1.72E-09mmHg at 25°C
• Boiling Point: 496 °C at 760 mmHg
• Flash Point: 253.8 °C

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of bis(4-methoxybenzyl)diselane

There total 10 articles about bis(4-methoxybenzyl)diselane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-(2-propyl)-4-methoxybenzylideneamine (13033-52-8) → 1,2-bis(4-methoxybenzyl)diselane (62212-22-0)

Guidance literature:

With selenium; carbon monoxide; water; In tetrahydrofuran; triethylamine; at 100 ℃; for 3h; under 22501.8 Torr;

DOI:10.1002/adsc.200404380

Reference yield: 92.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) + 4-Methoxybenzyl alcohol (105-13-5) → 1,2-bis(4-methoxybenzyl)diselane (62212-22-0)

Guidance literature:

N,N-dimethyl-formamide; 4-Methoxybenzyl alcohol; With phosphorus pentachloride; In acetonitrile; at 20 ℃;

With BH₂Se₃^(1-)*Na⁽¹⁺⁾; In tetrahydrofuran; acetonitrile; at 20 ℃;

DOI:10.1055/s-0035-1561579

Reference yield: 91.0%

4-methoxy-benzaldehyde (123-11-5) → 1,2-bis(4-methoxybenzyl)diselane (62212-22-0) + 2,4,6-Tris-(4-methoxy-phenyl)-[1,3,5]triselenane (127275-29-0)

Guidance literature:

With bis(trimethylsilyl)selenide; boron trifluoride diethyl etherate; In dichloromethane; at 0 ℃; for 9h;

DOI:10.1016/S0040-4039(01)93851-1

upstream raw materials:

4-methoxy-benzaldehyde

4-Methoxybenzyl alcohol

2,3-dimethyl-buta-1,3-diene

p-methoxybenzyl chloride

Downstream raw materials:

Fmoc-Sec(Mob)-OMe

Refernces

• 1、 Xu, Hang,Yan, Zhong-zuo,Guo, Meng-bi,An, Ran,Wang, Xin,Zhang, Rui,Mou, Yan-hua,Hou, Zhuang,Guo, Chun. "Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections". . . Retrieved 2021/03/16.
• 2、 Chen, Feng,Li, Fuhai,Zeng, Qingle. "Synthesis of Dibenzylic Diselenides from Elemental Selenium and Benzylic Quaternary Ammonium Salts". supporting information. p. 5605 - 5608. Retrieved 2021/11/11.