1-Bromo-4-chloro-2-fluorobenzene

Base Information

• Chemical Name: 1-Bromo-4-chloro-2-fluorobenzene
• CAS No.: 1996-29-8
• Molecular Formula: C6H3BrClF
• Molecular Weight: 209.445
• Hs Code.: 29039990
• Mol file: 1996-29-8.mol

Synonyms:4-Bromo-1-chloro-3-fluorobenzene;

Chemical Property of 1-Bromo-4-chloro-2-fluorobenzene

Chemical Property:

• Appearance/Colour: CLEAR COLORLESS TO PALE YELLOW LIQUID
• Refractive Index: n20/D 1.556(lit.)
• Boiling Point: 187.3 °C at 760 mmHg
• Flash Point: 67.1 °C
• PSA: 0.00000
• Density: 1.719 g/cm³
• LogP: 3.24160
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: INSOLUBLE

Purity/Quality:

98% ^*data from raw suppliers

1-Bromo-4-chloro-2-fluorobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26-24/25

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Uses: A 2,4-dihalofluorobenzene derivative with antibacterial and antifungal activities. 1-Bromo-4-chloro-2-fluorobenzene may be used in the preparation of benzonorbornadiene derivative. It may also be used as a starting material in the multi-step synthesis of AZD3264, an IKK2 (inhibitor of nuclear factor κ-B kinase-2) inhibitor.

Technology Process of 1-Bromo-4-chloro-2-fluorobenzene

There total 4 articles about 1-Bromo-4-chloro-2-fluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

→ 1-bromo-4-chloro-2-fluorobenzene (1996-29-8)

Guidance literature:

With bromine; dibromoisocyanuric acid; In dichloromethane; at 20 ℃; for 24h; UV-irradiation;

Reference yield:

2-fluoro-4-chloroaniline (57946-56-2) → 1-bromo-4-chloro-2-fluorobenzene (1996-29-8)

Guidance literature:

2-fluoro-4-chloroaniline; With hydrogen bromide; sodium nitrite; In water; at -10 ℃; for 0.5h;

With hydrogen bromide; copper(I) bromide; In water; at -10 - 55 ℃; for 0.333333h;

Reference yield:

copper(I) sulfate + 2-fluoro-4-chloroaniline (57946-56-2) → 1-bromo-4-chloro-2-fluorobenzene (1996-29-8)

Guidance literature:

With sodium bromide; copper(I) bromide; sodium sulfite; sodium nitrite; In hydrogen bromide;

upstream raw materials:

2-fluoro-4-chloroaniline

Downstream raw materials:

3-bromo-6-chloro-2-fluorobenzoic acid

Refernces

• 1、 -. "Substituted piperazines". . . Retrieved 2008/06/13.