Cbz-Gly-D-Trp

Base Information

• Chemical Name: Cbz-Gly-D-Trp
• CAS No.: 202595-75-3
• Molecular Formula: C21H21N3O5
• Molecular Weight: 395.40900
• DSSTox Substance ID: DTXSID601238729
• Mol file: 202595-75-3.mol

Synonyms:202595-75-3;Cbz-Gly-D-Trp;BDBM36229;DTXSID601238729;D-Tryptophan, N-[(phenylmethoxy)carbonyl]glycyl-;EN300-18545501;(2R)-2-(2-{[(BENZYLOXY)CARBONYL]AMINO}ACETAMIDO)-3-(1H-INDOL-3-YL)PROPANOIC ACID

Chemical Property of Cbz-Gly-D-Trp

Chemical Property:

• PSA: 120.52000
• LogP: 2.98800
• Storage Temp.: -15°C
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 9
• Exact Mass: 395.14812078
• Heavy Atom Count: 29
• Complexity: 579

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC(=O)NCC(=O)NC(CC2=CNC3=CC=CC=C32)C(=O)O
• Isomeric SMILES: C1=CC=C(C=C1)COC(=O)NCC(=O)N[C@H](CC2=CNC3=CC=CC=C32)C(=O)O

Technology Process of Cbz-Gly-D-Trp

There total 2 articles about Cbz-Gly-D-Trp which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(benzyloxycarbonyl)-D-tryptophan (2279-15-4) → Cbz-Gly-D-Trp (202595-75-3)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium; methanol; acetic acid / Hydrogenation

2: aqueous NaOH

With methanol; sodium hydroxide; palladium; acetic acid;

Reference yield:

N-(benzyloxycarbonyl)glycyl chloride (15050-24-5) + D-tryptophan (153-94-6,27732-43-0,80206-30-0,27813-82-7) → Cbz-Gly-D-Trp (202595-75-3)

Guidance literature:

With sodium hydroxide;

upstream raw materials:

N-(benzyloxycarbonyl)glycyl chloride

D-tryptophan

N-(benzyloxycarbonyl)-D-tryptophan