Sodium stibogluconate

Base Information

• Chemical Name: Sodium stibogluconate
• CAS No.: 16037-91-5
• Deprecated CAS: 12001-86-4,35-03-0
• Molecular Formula: C12H20 O17 Sb2 . 9 H2 O . 3 Na
• Molecular Weight: 1048.91
• European Community (EC) Number: 642-992-3
• Wikipedia: Sodium_stibogluconate
• Mol file: 16037-91-5.mol

Synonyms:Antimony Gluconate Sodium;Antimony Gluconic Acid;Antimony Sodium Gluconate;Antimony Sodium Gluconates;Myostibin;Pentostam;Sodium Gluconates, Antimony;Sodium Stibogluconate;Sodium, Stibogluconate;Solustibosan;Stibatin;Stibogluconate Sodium;Stibogluconate, Sodium;Triostam

Chemical Property of Sodium stibogluconate

Chemical Property:

• Vapor Pressure: 4.95E-21mmHg at 25°C
• Boiling Point: 673.6°Cat760mmHg
• Flash Point: 375.2°C
• PSA: 399.06000
• Density: g/cm³
• LogP: -8.81310
• Storage Temp.: 2-8°C
• Solubility.: H2O: 1 mg/mL at ~75 °C
• Hydrogen Bond Donor Count: 15
• Hydrogen Bond Acceptor Count: 26
• Rotatable Bond Count: 6
• Exact Mass: 908.92682
• Heavy Atom Count: 43
• Complexity: 699

Purity/Quality:

99% ^*data from raw suppliers

Sodium Stibogluconate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,N
• Hazard Codes: Xn,N
• Statements: 20/22-51/53
• Safety Statements: 61

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C(C1C(C(O[Sb](=O)(O1)O[Sb]2(=O)OC(C(C(O2)C(=O)[O-])O)C(CO)O)C(=O)[O-])O)O)O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].[Na+]
• Isomeric SMILES: C([C@H]([C@@H]1[C@@H]([C@@H](O[Sb](=O)(O1)O[Sb]2(=O)O[C@@H]([C@@H]([C@@H](O2)C(=O)[O-])O)[C@@H](CO)O)C(=O)[O-])O)O)O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].[Na+]
• Recent ClinicalTrials: LXE408 for Treatment of Visceral Leishmaniasis in Ethiopia, a Proof of Concept Study
• Description: Sodium stibogluconate is a pentavalent antimony derivative that is highly active against Leishmania amastigotes in macrophages. Sodium stibogluconate has diverse effects on both this intracellular parasite and its host cell.
• Uses: Sodium Stibogluconate is an intermediate used to prepare Dihydropyrido[2,3-d]pyrimidines as a new class of antileishmanial agents. Sodium stibogluconate is a pentavalent antimony derivative that is highly active against Leishmania amastigotes in macrophages. Sodium stibogluconate has diverse effects on both this intracellular parasite and its host cell.
• Clinical Use: Sodium antimony gluconate (Pentostam) is a pentavalent antimonialcompound intended primarily for the treatment ofvarious forms of leishmaniasis. It is available from the CDCas the disodium salt, which is chemically stable and freelysoluble in water. The 10% aqueous solution used for eitherintramuscular or intravenous injection has a pH of approximately5.5. Like all antimonial drugs, this drug has a lowtherapeutic index, and patients undergoing therapy with itshould be monitored carefully for signs of heavy metal poisoning.Other organic antimonial compounds are used primarilyfor the treatment of schistosomiasis and other flukes.The antileishmanial action of sodium stibogluconate requiresits reduction to the trivalent form, which is believedto inhibit phosphofructokinase in the parasite. Visceral, cutaneous and mucocutaneous leishmaniasisThe combination with paromomycin has been used in unresponsive cases and in relapses of visceral and cutaneous leishmaniasis.
• Drug interactions: otentially hazardous interactions with other drugsP Antifungals: possible increased risk of arrhythmias with amphotericin - give 14 days apart.