L-Tame

Base Information

• Chemical Name: L-Tame
• CAS No.: 1784-03-8
• Molecular Formula: C14H23ClN4O4S
• Molecular Weight: 378.88
• Hs Code.: 29252900
• NSC Number: 80683
• Mol file: 1784-03-8.mol

Synonyms:L-TAME;EINECS 217-235-1;Tos-Arg-OMe . HCl;SCHEMBL11880215;NSC80683;NSC-80683;AKOS024370830;PD055905;FT-0633838;(2-CHLORO-ETHYL)-(2-CHLORO-2-PHENYL-ETHYL)-METHYL-AMINE

Chemical Property of L-Tame

Chemical Property:

• Appearance/Colour: white fine crystalline powder
• Vapor Pressure: 6.73E-12mmHg at 25°C
• Melting Point: 145-147 °C
• Refractive Index: -14 ° (C=4, H2O)
• Boiling Point: 544.1 °C at 760mmHg
• Flash Point: 282.9 °C
• PSA: 142.75000
• LogP: 3.54280
• Storage Temp.: −20°C
• Solubility.: methanol: 50 mg/mL, clear, colorless
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 9
• Exact Mass: 378.1128541
• Heavy Atom Count: 24
• Complexity: 503

Purity/Quality:

98%,99%, ^*data from raw suppliers

TAME Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-24/25-37/39-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)S(=O)(=O)NC(CCCN=C(N)N)C(=O)OC.Cl
• Description: TAME (1784-03-8) binds to the ubiquitin ligase anaphase-promoting complex (APC) preventing its activation by Cdc20 and Cdh1 and resulting in mitotic arrest.1,2
• Uses: enzyme inhibitor Substrate for trypsin, thrombin, plasmin and other proteases. N-4-Tosyl-L-arginine Methyl Ester Hydrochloride acts as a synthetic substrate of serine proteases and thus is used to determine serine proteases from diverse organic sources.

Technology Process of L-Tame

There total 3 articles about L-Tame which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + Nα-p-tosyl-L-arginine (1159-15-5) → Nα-tosyl-L-arginine methyl ester hydrochloride (1784-03-8)

Guidance literature:

With hydrogenchloride;

Reference yield:

L-arginine (74-79-3,25212-18-4) → Nα-tosyl-L-arginine methyl ester hydrochloride (1784-03-8)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH solution; diethyl ether

2: hydrogen chloride

With hydrogenchloride; sodium hydroxide; diethyl ether;

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → Nα-tosyl-L-arginine methyl ester hydrochloride (1784-03-8)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH solution; diethyl ether

2: hydrogen chloride

With hydrogenchloride; sodium hydroxide; diethyl ether;

upstream raw materials:

methanol

N^α-p-tosyl-L-arginine

L-arginine

p-toluenesulfonyl chloride

Downstream raw materials:

N^α-(toluene-4-sulfonyl)-L-arginine amide; hydrochloride

N^α-p-tosyl-L-arginine