ZM 323881 hydrochloride

Base Information

• Chemical Name: ZM 323881 hydrochloride
• CAS No.: 193000-39-4
• Molecular Formula: C22H18FN3O2.ClH
• Molecular Weight: 411.85700
• Mol file: 193000-39-4.mol

Synonyms:ZM 323881 HCl;

Chemical Property of ZM 323881 hydrochloride

Chemical Property:

• PSA: 67.27000
• LogP: 5.98050

Purity/Quality:

99% ^*data from raw suppliers

ZM323881Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Hydrochloride salt of ZM 323881, a potent and selective inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2) with application towards cancer treatments.

Technology Process of ZM 323881 hydrochloride

There total 1 articles about ZM 323881 hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

7-benzyloxy-4-chloroquinazoline hydrochloride + 2-fluoro-5-hydroxy-4-methylaniline (122455-85-0) → ZM 323881 hydrochloride (193000-39-4)

Guidance literature:

In (+/-)-2-pentanol;

upstream raw materials:

2-fluoro-5-hydroxy-4-methylaniline

Refernces

• 1、 -. "SUBSTITUTED QUINAZOLINES". . . Retrieved 2008/06/13.