1-Methoxy-2-(3-methoxyphenoxy)benzene

Base Information

• Chemical Name: 1-Methoxy-2-(3-methoxyphenoxy)benzene
• CAS No.: 1655-71-6
• Molecular Formula: C14H14O3
• Molecular Weight: 230.263
• Hs Code.: 2909309090
• DSSTox Substance ID: DTXSID30554400
• Nikkaji Number: J80.273E
• Wikidata: Q82435372
• Mol file: 1655-71-6.mol

Synonyms:1-Methoxy-2-(3-methoxyphenoxy)benzene;1655-71-6;benzene,1-methoxy-2-(3-methoxyphenoxy)-;SCHEMBL13791510;DTXSID30554400

Chemical Property of 1-Methoxy-2-(3-methoxyphenoxy)benzene

Chemical Property:

• Melting Point: 54.8°C
• Refractive Index: 1.5800 (estimate)
• Boiling Point: 327.5°C (estimate)
• PSA: 27.69000
• Density: 1.1450 (rough estimate)
• LogP: 3.49610
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 230.094294304
• Heavy Atom Count: 17
• Complexity: 220

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=CC=C1)OC2=CC=CC=C2OC

Technology Process of 1-Methoxy-2-(3-methoxyphenoxy)benzene

There total 13 articles about 1-Methoxy-2-(3-methoxyphenoxy)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromoanisole (578-57-4) → (2-methoxy-phenyl)-(3-methoxy-phenyl)-ether (1655-71-6)

Guidance literature:

With copper; at 350 ℃;

DOI:10.1017/S0025315401004842

Reference yield:

2-hydroxybromobenzene (95-56-7) → (2-methoxy-phenyl)-(3-methoxy-phenyl)-ether (1655-71-6)

Guidance literature:

Multi-step reaction with 2 steps

1: diluted KOH-solution

2: copper / 350 °C

With potassium hydroxide; copper;

DOI:10.1017/S0025315401004842

Reference yield:

2-chloro-4-methoxy-benzoic acid methyl ester (104253-45-4) → (2-methoxy-phenyl)-(3-methoxy-phenyl)-ether (1655-71-6)

Guidance literature:

Multi-step reaction with 4 steps

1: methanol. sodium methylate; copper-powder

3: aqueous HBr; acetic acid

4: aqueous methanol. NaOH

With sodium hydroxide; hydrogen bromide; sodium methylate; copper; acetic acid;

DOI:10.1021/ja01140a045

upstream raw materials:

3-methoxyphenyl bromide

potassium guaiacolate

2,3'-Oxy-di-phenol

dimethyl sulfate

Downstream raw materials:

O-methylresorcine

2-methoxy-phenol

2,3'-Oxy-di-phenol