3-(Diphenylphosphino)-1-propylamine

Base Information

• Chemical Name: 3-(Diphenylphosphino)-1-propylamine
• CAS No.: 16605-03-1
• Molecular Formula: C15H18NP
• Molecular Weight: 243.288
• Hs Code.: 2921499090
• European Community (EC) Number: 624-345-7
• NSC Number: 132586
• DSSTox Substance ID: DTXSID00299770
• Nikkaji Number: J495.186G
• Wikidata: Q82042417
• ChEMBL ID: CHEMBL158764
• Mol file: 16605-03-1.mol

Synonyms:16605-03-1;3-(Diphenylphosphino)-1-propylamine;3-(Diphenylphosphino)propan-1-amine;3-diphenylphosphanylpropan-1-amine;(3-Aminopropyl)diphenylphosphine;3-(DIPHENYLPHOSPHINO)PROPYLAMINE;1-Propanamine, 3-(diphenylphosphino)-;NSC132586;SCHEMBL474417;3-diphenylphosphino-propylamine;CHEMBL158764;3-Diphenylphosphanyl-propylamine;DTXSID00299770;DQZWMOWSTWWMPP-UHFFFAOYSA-N;MFCD00233832;AKOS015900175;CS-W018334;NSC-132586;SC11556;(3-Aminopropyl)diphenylphosphine;D4825;FT-0715490;D90335;A882351;J-010253;3-(Diphenylphosphino)-1-propylamine, technical, >=90% (GC);(3-AMINOPROPYL)DIPHENYLPHOSPHINE;3-(DIPHENYLPHOSPHINO)-1-PROPYLAMINE;3-(DIPHENYLPHOSPHINO)PROPAN-1-AMINE;3-DI(PHENYL)PHOSPHANYLPROPAN-1-AMINE

Chemical Property of 3-(Diphenylphosphino)-1-propylamine

Chemical Property:

• Vapor Pressure: 2.69E-05mmHg at 25°C
• Boiling Point: 357.7 °C at 760 mmHg
• Flash Point: 170.1 °C
• PSA: 39.61000
• LogP: 3.16840
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive.: Air Sensitive
• Water Solubility.: Not miscible or difficult to mix in water.
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 5
• Exact Mass: 243.117686576
• Heavy Atom Count: 17
• Complexity: 177

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-(Diphenylphosphino)-1-propylamine >97.0%(T) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)P(CCCN)C2=CC=CC=C2
• Uses: 3-(Diphenylphosphino)propylamine is used as a paharmaceutical.

Technology Process of 3-(Diphenylphosphino)-1-propylamine

There total 13 articles about 3-(Diphenylphosphino)-1-propylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(2-cyanoethyl)diphenylphosphine (5032-65-5) → (3-aminopropyl)diphenylphosphine (16605-03-1)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 18h; Heating;

DOI:10.1021/jo00102a050

Reference yield: 80.0%

triphenylphosphine (603-35-0) + propane-1,3-diamine monohydrochloride → (3-aminopropyl)diphenylphosphine (16605-03-1)

Guidance literature:

triphenylphosphine; With ammonia; sodium; at -78 ℃; for 3h;

propane-1,3-diamine monohydrochloride; In tetrahydrofuran; at -78 ℃; Reflux;

DOI:10.1021/ja2049786

Reference yield: 80.0%

3-chloropropylamine hydrochloride (6276-54-6) + sodium diphenylphosphide (4376-01-6) → (3-aminopropyl)diphenylphosphine (16605-03-1)

Guidance literature:

In tetrahydrofuran; 1. -78 deg C, 2 h, 2. 60-70 deg C, 8 h, reflux;

DOI:10.1246/bcsj.64.2372

upstream raw materials:

3-chloropropan-1-amine

potassium diphenylphosphine

1-chloro-3-azidopropane

lithium diphenylphosphide

Downstream raw materials:

γ aminopropyl phenyl phosphine

2-(PPh₂(CH₂)3NCH)C₆H₄OH

3-diphenylphosphinopropylaminocarbonylmethane

Rh(C₅(CH₃)5)Cl(H₂N(CH₂)3P(C₆H₅)2)⁽¹⁺⁾*B(C₆H₅)4^(1-)=Rh(C₅(CH₃)5)Cl(H₂N(CH₂)3P(C₆H₅)2)(B(C₆H₅)4)

Refernces

• 1、 Chu, Wan-Yi,Gilbert-Wilson, Ryan,Rauchfuss, Thomas B.,Van Gastel, Maurice,Neese, Frank. "Cobalt Phosphino-α-Iminopyridine-Catalyzed Hydrofunctionalization of Alkenes: Catalyst Development and Mechanistic Analysis". supporting information. p. 2900 - 2914. Retrieved 2016/11/02.
• 2、 Jia, Wenli,Chen, Xuanhua,Guo, Rongwei,Sui-Seng, Christine,Amoroso, Dino,Lough, Alan J.,Abdur-Rashid, Kamaluddin. "Aminophosphine ligands R2P(CH2)nNH 2 and ruthenium hydrogenation catalysts RuCl2(R 2P(CH2)nNH2)2". experimental part. p. 8301 - 8307. Retrieved 2010/03/04.