Homatropine hydrobromide

Base Information

• Chemical Name: Homatropine hydrobromide
• CAS No.: 51-56-9
• Molecular Formula: C16H21 N O3 . Br H
• Molecular Weight: 356.26
• Hs Code.: 2933990090
• European Community (EC) Number: 200-105-3
• UNII: BEW7469QZ0
• DSSTox Substance ID: DTXSID5045099
• NCI Thesaurus Code: C29093
• RXCUI: 235428
• Pharos Ligand ID: WNGC9BRLVNCA
• ChEMBL ID: CHEMBL1319362
• Mol file: 51-56-9.mol

Synonyms:AK-Homatropine;Homatropin - POS;homatropine;homatropine hydrobromide, (endo-(+-)-isomer);homatropine hydrochloride, (endo-(+-)-isomer);homatropine sulfate (1:1), (3(R)-endo)-isomer;homatropine sulfate (1:1), (3(S)-endo)-isomer;homatropine sulfate (2:1), endo-isomer;homatropine, (3(S)-endo)-isomer;homatropine, exo-(+-)-isomer;I - Homatrine;Isopto Homatropine;Minims-Homatropin;Minims-Homatropine Hydrobromide

Chemical Property of Homatropine hydrobromide

Chemical Property:

• Appearance/Colour: Colorless or white powder. Bromine-like odor.
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 214-217 ºC
• Boiling Point: 434.9 °C at 760 mmHg
• Flash Point: 216.8 °C
• PSA: 49.77000
• Density: 1.21g/cm³
• LogP: 2.78440
• Storage Temp.: 2-8°C
• Solubility.: Freely soluble in water, sparingly soluble in alcohol.
• Water Solubility.: soluble
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 355.07831
• Heavy Atom Count: 21
• Complexity: 340

Purity/Quality:

99% ^*data from raw suppliers

rac Homatropine Hydrobromide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 23/24/25
• Safety Statements: 45-24/25-22

MSDS Files:

Useful:

• Canonical SMILES: CN1C2CCC1CC(C2)OC(=O)C(C3=CC=CC=C3)O.Br
• Isomeric SMILES: CN1[C@@H]2CC[C@H]1CC(C2)OC(=O)C(C3=CC=CC=C3)O.Br
• Description: Homatropine is an anticholinergic agent. It reduces acetylcholine-induced contractions of isolated goat detrusor muscle strips when used at a concentration of 5 μM. Homatropine (1 μM) inhibits acetylcholine- or methacholine-induced contraction of isolated rat anococcygeus muscle. It inhibits serotonin- or thrombin-induced platelet aggregation in isolated sheep platelet-rich plasma (IC50s = 4.3 and 100 μM, respectively). Topical ophthalmic administration of homatropine induces partial mydriasis in Angora goats.
• Uses: Homatropine is an anticholinergic agent. Homatropine acts as an inhibitor of the muscarinic acetylcholine receptors. Homatropine is used in eye drops as a cycloplegic and as a mydriatic, to dilate the pupil. anticholinergic (opthalmic)
• Clinical Use: Homatropine hydrobromide is used topically to paralyzethe ciliary structure of the eye (cycloplegia) and to effectmydriasis. It behaves very much like atropine but is weakerand less toxic. In the eye, it acts more rapidly but less persistentlythan atropine. Dilation of the pupil takes place inabout 15 to 20 minutes, and the action subsides in about24 hours. By using a miotic, such as physostigmine, it ispossible to restore the pupil to normality in a few hours.

Technology Process of Homatropine hydrobromide

There total 1 articles about Homatropine hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ homatropine hydrobromide (51-56-9)

Guidance literature:

Tropin (III) 1. Phenylglyoxylsaeure-chlorid 2. (Rkprod.), NaBH4 3. 40percent-ig. HBr;

DOI:10.1007/BF00778015

Reference yield:

homatropine hydrobromide (51-56-9) → MANDELIC ACID (611-71-2,611-72-3,17199-29-0,90-64-2) + 3-tropanol (120-29-6)

Guidance literature:

at 20 - 47 ℃; Kinetics; in wss.Loesungen vom pH 7 bis pH 12.5.Hydrolysis;

Reference yield:

2,13-di(3,4,5-trimethoxyphenyl)-1,3,12,14-tetrathia[5.5]paracyclophane + homatropine hydrobromide (51-56-9) → C36H40O6S4*C16H21NO3*BrH

Guidance literature:

With trifluoroacetic acid; In chloroform-d1;

DOI:10.1021/acs.orglett.7b00401

Downstream raw materials:

MANDELIC ACID

3-tropanol