Goniodiol diacetate

Base Information Edit

Chemical Name:Goniodiol diacetate
CAS No.:136778-40-0
Molecular Formula:C17H18O6
Molecular Weight:318.326
Hs Code.:
Mol file:136778-40-0.mol

Synonyms:Goniodiol diacetate;(+)-goniodiol-diacetate;(+)-goniodiol diacetate;

Suppliers and Price of Goniodiol diacetate

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Arctom
Goniodioldiacetate ≥98%
5mg
$ 463.00

Total 4 raw suppliers

Chemical Property of Goniodiol diacetate Edit

Chemical Property:

Melting Point:150 °C (petroleum ether)
Boiling Point:386.4±12.0 °C(Predicted)
PSA：78.90000
Density:1.236±0.06 g/cm3(Predicted)
LogP:2.09420

Purity/Quality:

99.90% ^*data from raw suppliers

Goniodioldiacetate ≥98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Goniodiol diacetate

There total 24 articles about Goniodiol diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 108-24-7
acetic anhydride

: 146236-73-9,96422-52-5
(+)-goniodiol

: 136778-40-0
7,8-di-O-acetyl-goniodiol

Guidance literature:: With pyridine;

Reference yield:

: 4407-36-7
(2E)-3-phenyl-2-propen-1-ol

: 136778-40-0
7,8-di-O-acetyl-goniodiol

Guidance literature:: Multi-step reaction with 14 steps

1: 86 percent / TBHP, Ti(OiPr)4, L-(+)-diisopropyl tartrate, molecular sieves 4 Angstroem / CH₂Cl₂ / -20 °C

2: 90 percent / CHCl₃ / -20 - 0 °C

3: imidazole / tetrahydrofuran / Ambient temperature

4: 15percent aq. NaOH / tetrahydrofuran / Ambient temperature

5: p-TsOH / CH₂Cl₂ / Ambient temperature

6: nBu₄NF / tetrahydrofuran / 0 °C

7: Me₂SO, (COCl)2, Et₃N / CH₂Cl₂ / -78 - -20 °C

8: tetrahydrofuran / -78 - -30 °C

9: 84 percent / TBHP, VO(acac)2 / CH₂Cl₂ / 0 °C

10: 1) CrO₃, 2) NaBH(OAc)3 / 1) HOAc, 25 deg C to 30 deg C, 15 min, 2) iPrOH, HOAc, -10 deg C to r.t.

11: 98 percent / pyridine, DMAP / CH₂Cl₂ / 4 h / Ambient temperature

12: 87 percent / Zn-Hg, HCl / diethyl ether / 4 h / Ambient temperature

13: 85 percent / DBU / benzene / 2 h / 80 °C

14: 1) TFA, 2) DMAP, pyridine / 1) H₂O, r.t., 4 h, 2) CH₂Cl₂, 0 deg C to r.t.

With pyridine; 1H-imidazole; chromium(VI) oxide; titanium(IV) isopropylate; hydrogenchloride; tert.-butylhydroperoxide; dmap; sodium hydroxide; oxalyl dichloride; bis(acetylacetonate)oxovanadium; L-(+)-diisopropyl tartrate; 4 A molecular sieve; tetrabutyl ammonium fluoride; sodium tris(acetoxy)borohydride; toluene-4-sulfonic acid; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; mercury; trifluoroacetic acid; zinc; In tetrahydrofuran; diethyl ether; dichloromethane; chloroform; benzene;
DOI:10.1039/c39950000743

Reference yield:

: 474087-63-3
(4R,5R)-4-Phenyl-5-vinyl-[1,3]dioxolan-2-one

: 136778-40-0
7,8-di-O-acetyl-goniodiol

Guidance literature:: Multi-step reaction with 5 steps

1: 71 percent / PdCl₂(CH₃CN)2 / dimethylformamide; H₂O / 1 h / 0 °C

2: 91 percent / Et₃N; DMAP / 1 h / 0 °C

3: 87 percent / AD-mix-β / 16 h / 0 °C

4: 72 percent / PTS / toluene / 80 °C

5: Et₃N; DMAP / 1 h / 0 °C

With dmap; AD-mix-β; pyridinium p-toluenesulfonate; triethylamine; dichloro bis(acetonitrile) palladium(II); In water; N,N-dimethyl-formamide; toluene; 3: Sharpless dihydroxylation;
DOI:10.1055/s-2002-32977