N'-(1-Methylazepan-4-yl)benzohydrazine

Base Information

• Chemical Name: N'-(1-Methylazepan-4-yl)benzohydrazine
• CAS No.: 117078-69-0
• Molecular Formula: C₁₄H₂₁N₃O*ClH
• Molecular Weight: 283.801
• Hs Code.: 2924296000
• Mol file: 117078-69-0.mol

Synonyms:

Chemical Property of N'-(1-Methylazepan-4-yl)benzohydrazine

Chemical Property:

• Melting Point: >78°C (dec.)
• PSA: 47.86000
• LogP: 3.11090
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility.: DMSO (Slightly, Heated, Sonicated), Methanol (Slightly, Heated), Water (Slightly

Purity/Quality:

99% ^*data from raw suppliers

N''-(1-Methylazepan-4-yl)benzohydrazideHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An intermediate in the preparation of Azelastine (A808250). An intermediate in the preparation of Azelastine (A808250(P)), which is an orally active H1-hystamine receptor antagonist and an antihistaminic.

Technology Process of N'-(1-Methylazepan-4-yl)benzohydrazine

There total 1 articles about N'-(1-Methylazepan-4-yl)benzohydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methyl-1,2,3,5,6,7-hexahydroazepin-4-one (1859-33-2) + benzoic acid hydrazide (613-94-5) → 2-Benzoyl-1-(hexahydro-1-methyl-1H-azepin-4-yl)hydrazin-hydrochlorid (117078-69-0)

Guidance literature:

With sodium tetrahydroborate; Multistep reaction; 1.) CH₃OH, room temp.;

DOI:10.1002/ardp.19883210406

upstream raw materials:

1-methyl-1,2,3,5,6,7-hexahydroazepin-4-one

benzoic acid hydrazide

Refernces