Piperidin-3-ylmethanamine

Base Information

• Chemical Name: Piperidin-3-ylmethanamine
• CAS No.: 23099-21-0
• Molecular Formula: C6H14N2
• Molecular Weight: 114.191
• Hs Code.: 2933399090
• European Community (EC) Number: 245-428-0
• DSSTox Substance ID: DTXSID70945777
• Nikkaji Number: J318.402A
• Mol file: 23099-21-0.mol

Synonyms:piperidin-3-ylmethanamine;23099-21-0;3-(AMINOMETHYL)PIPERIDINE;3-Aminomethyl-piperidine;3-piperidinemethanamine;3-aminomethylpiperidine;Piperidine-3-methylamine;EINECS 245-428-0;3-(AMINOMETHYL)-1-PIPERIDINE;3-Aminomethyl piperidine;(S)-C-PIPERIDIN-3-YL-METHYLAMINE;3-Nitrocinnamicacid;Piperidine-3-methanamine;(piperidin-3-yl)methanamine;rac.-3-aminomethylpiperidine;1-(Piperidin-3-yl)methanamine;SCHEMBL1036463;DTXSID70945777;AMY11508;YAA09921;MFCD03427344;3-(aminomethyl)piperidine, AldrichCPR;AKOS005207014;AB01087;SB41242;SB47830;AS-44394;A2518;CS-0171558;FT-0600841;EN300-295862

Chemical Property of Piperidin-3-ylmethanamine

Chemical Property:

• Appearance/Colour: White Solid
• Vapor Pressure: 1.07mmHg at 25°C
• Refractive Index: 1.456
• Boiling Point: 176.9 °C at 760 mmHg
• PKA: 10.12±0.10(Predicted)
• Flash Point: 66.7 °C
• PSA: 38.05000
• Density: 0.897 g/cm³
• LogP: 0.97380
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 114.115698455
• Heavy Atom Count: 8
• Complexity: 63.5

Purity/Quality:

98%,99%, ^*data from raw suppliers

Piperidin-3-ylmethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R34:Causes burns.
• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(CNC1)CN

Technology Process of Piperidin-3-ylmethanamine

There total 4 articles about Piperidin-3-ylmethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

nipecotamide (4138-26-5,168749-30-2) → 3-Aminomethylpiperidine (23099-21-0,174073-64-4)

Guidance literature:

nipecotamide; With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 24h;

With sodium sulfate; In tetrahydrofuran;

Reference yield:

nicotinamide (98-92-0,1255150-40-3) → 3-Aminomethylpiperidine (23099-21-0,174073-64-4)

Guidance literature:

With sulfuric acid; Blei-Kathode;

Reference yield:

sulfuric acid (7664-93-9) + nicotinamide (98-92-0,1255150-40-3) → 3-Aminomethylpiperidine (23099-21-0,174073-64-4)

Guidance literature:

Electrolysis;

upstream raw materials:

nicotinamide

sulfuric acid

nipecotamide

Downstream raw materials:

PtCl2(3-aminomethylpiperidine)

C₁₉H₁₉ClN₆

(±)-(1-benzylpiperidin-3-yl)methanamine

N-{[1-(5-chloro-2-hydroxybenzoyl)piperidin-3-yl]methyl}-2,2,2-trifluoroacetamide

Refernces

• 1、 -. "2,5-substituted pyrimidine derivatives-CCR-3 receptor antagonists". Page/Page column 26-27. . Retrieved 2010/02/05.