N-Acetyl-L-prolinamide

Base Information

• Chemical Name: N-Acetyl-L-prolinamide
• CAS No.: 16395-58-7
• Molecular Formula: C7H12N2O2
• Molecular Weight: 156.184
• Hs Code.: 2933990090
• Mol file: 16395-58-7.mol

Synonyms:2-Pyrrolidinecarboxamide,1-acetyl-, (S)-;2-Pyrrolidinecarboxamide, 1-acetyl-, L- (8CI);1-Acetylprolinamide;N-Acetylprolinamide;

Chemical Property of N-Acetyl-L-prolinamide

Chemical Property:

• Appearance/Colour: White Powder
• Vapor Pressure: 5.38E-07mmHg at 25°C
• Melting Point: 178-180 °C
• Refractive Index: 1.519
• Boiling Point: 411.9 °C at 760 mmHg
• PKA: 15.41±0.20(Predicted)
• Flash Point: 202.9 °C
• PSA: 63.40000
• Density: 1.206 g/cm³
• LogP: 0.12080
• Storage Temp.: Store at RT.

Purity/Quality:

98%min ^*data from raw suppliers

Acetyl-L-proline amide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Acetyl-L-prolinamide

There total 8 articles about N-Acetyl-L-prolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.2%

(S)-1-Acetyl-pyrrolidine-2-carbonyl chloride (70935-35-2,72983-26-7) → N-acetyl-L-prolinamide (16395-58-7)

Guidance literature:

With ammonium hydroxide; In dichloromethane; at 30 ℃; for 3h; Temperature;

Reference yield: 90.0%

ethyl ester of N-acetyl-L-proline (23037-82-3,125347-82-2) → N-acetyl-L-prolinamide (16395-58-7,30130-35-9,136051-77-9)

Guidance literature:

With ammonia; In methanol; for 240h; Ambient temperature;

DOI:10.1007/BF00831694

Reference yield: 80.0%

acetyl chloride (75-36-5) + L-prolinamide (7531-52-4) → N-acetyl-L-prolinamide (16395-58-7)

Guidance literature:

With sodium 2-ethylhexanoic acid; In tetrahydrofuran;

DOI:10.1016/S0040-4039(98)01546-9

upstream raw materials:

vinyl acetate

L-prolinamide

acetic anhydride

L-proline

Downstream raw materials:

(S)-1-acetyl-N-tosylpyrrolidine-2-carboxamide

C₁₃H₁₅N₃O₆S

L-prolinamide

(S)-1-acetylpyrrolidine-2-carbonitrile

Refernces

• 1、 Thorat, Prashant B.,Goswami, Santosh V.,Khade, Bhimrao C.,Bhusare, Sudhakar R.. "Organocatalyzed Baylis-Hillman reaction: An enantioselective approach". . p. 1320 - 1325. Retrieved 2012/11/06.
• 2、 Chen,Chen,Chen,Wang. "Vinyl carboxylate an acylating reagent for selective acylation of amines and diols". . p. 3583 - 3584. Retrieved 2007/10/02.