H-TYR-PHE-LEU-PHE-ARG-PRO-ARG-ASN-NH2

Base Information

• Chemical Name: H-TYR-PHE-LEU-PHE-ARG-PRO-ARG-ASN-NH2
• CAS No.: 98395-75-6
• Molecular Formula: C54H78 N16 O10
• Molecular Weight: 1111.3
• Mol file: 98395-75-6.mol

Synonyms:NeuromedinU 8 (pig spinal cord); 18-25-Pig neuromedin U; 76: PN: US20060293232 TABLE: 1unclaimed sequence; L-Aspartamide,L-tyrosyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L-arginyl-L-prolyl-L-arginyl-;Neuromedin U 8 (pig); Neuromedin U octapeptide; Porcine neuromedin U-8

Chemical Property of H-TYR-PHE-LEU-PHE-ARG-PRO-ARG-ASN-NH2

Chemical Property:

• PSA: 451.14000
• LogP: 4.34660
• Storage Temp.: -15°C

Purity/Quality:

98%Min ^*data from raw suppliers

Neuromedin U-8 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-TYR-PHE-LEU-PHE-ARG-PRO-ARG-ASN-NH2

There total 1 articles about H-TYR-PHE-LEU-PHE-ARG-PRO-ARG-ASN-NH2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Z(OMe)-Tyr-Phe-Leu-Phe-Arg(Mts)-Pro-Arg(Mts)-Asn-NH2 (112674-49-4) → H-Tyr-Phe-Leu-Phe-Arg-Pro-Arg-Asn-NH2 (98395-75-6)

Guidance literature:

With ammonium hydroxide; ammonium fluoride; trimethylsilyl trifluoromethanesulfonate; 3-methyl-phenol; methoxybenzene; Yield given. Multistep reaction; 1.) TFA, 60 min.; 2.) pH = 8.0;

DOI:10.1248/cpb.35.1076

Reference yield: 73.0%

H-Tyr-Phe-Leu-Phe-Arg-Pro-Arg-Asn-NH2 (98395-75-6) → H-[Tyr(3'-I)]-Phe-Leu-Phe-Arg-Pro-Arg-Asn-NH2

Guidance literature:

With 1,3,4,6-tetrachloro-3α,6α-diphenyl glycoluril; sodium iodide; In aq. phosphate buffer; at 20 ℃; for 0.0166667h; pH=7;

DOI:10.1021/acsmedchemlett.8b00105

upstream raw materials:

Z(OMe)-Tyr-Phe-Leu-Phe-Arg(Mts)-Pro-Arg(Mts)-Asn-NH₂

Refernces