2,5-Dichlorophenylhydrazine hydrochloride

Base Information

• Chemical Name: 2,5-Dichlorophenylhydrazine hydrochloride
• CAS No.: 50709-35-8
• Molecular Formula: C6H6Cl2N2^.HCl
• Molecular Weight: 213.494
• Hs Code.: 29280000
• European Community (EC) Number: 256-729-1
• DSSTox Substance ID: DTXSID90198763
• Mol file: 50709-35-8.mol

Synonyms:50709-35-8;2,5-Dichlorophenylhydrazine hydrochloride;(2,5-dichlorophenyl)hydrazine hydrochloride;2,5-Dichlorophenylhydrazine HCl;2,5-Dichlorophenylhydrazine, HCl;(2,5-Dichlorophenyl)hydrazine monohydrochloride;Hydrazine, (2,5-dichlorophenyl)-, monohydrochloride;(2,5-dichlorophenyl)hydrazine;hydrochloride;EINECS 256-729-1;AC-4402;2,5-Dichlorophenylhydrazinehydrochloride;D03TDE;SCHEMBL967050;DTXSID90198763;RQZTURFFWSJCMT-UHFFFAOYSA-N;MFCD00052266;AKOS001476036;CS-W014961;GS-3049;SB78700;(2,5-dichlorophenyl)hydrazinehydrochloride;A7520;FT-0639934;1-(2,5-dichlorophenyl)hydrazine hydrochloride;EN300-96340;2,5-Dichlorophenylhydrazine hydrochloride, 98%;I10041;Z56973922;GABAA receptor inverse agonist (Alzheimer's disease), Dainippon Sumitomo Pharma

Chemical Property of 2,5-Dichlorophenylhydrazine hydrochloride

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Vapor Pressure: 0.00848mmHg at 25°C
• Melting Point: 208 °C (dec.)(lit.)
• Boiling Point: 266.8 °C at 760 mmHg
• Flash Point: 115.1 °C
• PSA: 38.05000
• LogP: 3.85430
• Storage Temp.: Inert atmosphere,Room Temperature
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 211.967481
• Heavy Atom Count: 11
• Complexity: 110

Purity/Quality:

99% ^*data from raw suppliers

2,5-Dichlorophenylhydrazine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1Cl)NN)Cl.Cl

Technology Process of 2,5-Dichlorophenylhydrazine hydrochloride

There total 3 articles about 2,5-Dichlorophenylhydrazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2,5 dichloroaniline (95-82-9) + ascorbic acid (50-81-7,98966-42-8) → 2,5-dichlorophenylhydrazine.HCl.xH2O + 1-(2,5-dichlorophenyl)hydrazine hydrochloride (50709-35-8)

Guidance literature:

With sodium nitrite; In hydrogenchloride; water;

Reference yield:

2,5 dichloroaniline (95-82-9) → 1-(2,5-dichlorophenyl)hydrazine hydrochloride (50709-35-8)

Guidance literature:

2,5 dichloroaniline; With hydrogenchloride; sodium nitrite; at 0 ℃;

With hydrogenchloride; tin(ll) chloride; at 0 ℃; for 1h;

DOI:10.1021/jm0401255

Reference yield:

2,5-dichloronitrobenzene (89-61-2) → 1-(2,5-dichlorophenyl)hydrazine hydrochloride (50709-35-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Fe; aq. NH₄Cl / 48 h / Heating

2.1: NaNO₂; aq. HCl / 0 °C

2.2: SnCl₂; aq. HCl / 1 h / 0 °C

With hydrogenchloride; iron; ammonium chloride; sodium nitrite;

DOI:10.1021/jm0401255

upstream raw materials:

2,5 dichloroaniline

2,5-dichloronitrobenzene

ascorbic acid

Downstream raw materials:

4-{1-[(2,5-Dichloro-phenyl)-hydrazono]-ethyl}-benzonitrile

N-(2,5-Dichloro-phenyl)-N'-[2,2,2-trifluoro-1-phenyl-eth-(Z)-ylidene]-hydrazine

4-chloro-2-(1-(2,5-dichlorophenyl)-1H-pyrazol-4-yl)-3,3,7-trimethyl-3H-indole

(E)-4-((2-(2,5-dichlorophenyl)hydrazono)methyl)-1-phenyl-1H-1,2,3-triazole

Refernces

• 1、 -. "Preparation of sodium-hydrogen exchanger type-1 inhibitors". . . Retrieved 2008/06/13.