16,28-Secosolanida-5,22(28)-diene-3β,16α-diol 16-acetate

Base Information

• Chemical Name: 16,28-Secosolanida-5,22(28)-diene-3β,16α-diol 16-acetate
• CAS No.: 36506-65-7
• Molecular Formula: C29H45NO3
• Molecular Weight: 455.681
• Mol file: 36506-65-7.mol

Synonyms:

Chemical Property of 16,28-Secosolanida-5,22(28)-diene-3β,16α-diol 16-acetate

Chemical Property:

• PSA: 58.89000
• LogP: 5.41050

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: From the alkaloidal fraction of the aerial portions of Veratrum album. subsp. lobelianum, this alkaloid is obtained by column chromatography on alumina. It has been shown spectroscopically and by chemical analysis to be 16-acetyl_x0002_veralosidine.

Technology Process of 16,28-Secosolanida-5,22(28)-diene-3β,16α-diol 16-acetate

There total 3 articles about 16,28-Secosolanida-5,22(28)-diene-3β,16α-diol 16-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetic anhydride (108-24-7) + solasodine (126-17-0) → pseudosolasodine diacetate (36506-65-7)

Guidance literature:

With zinc(II) chloride; In acetic acid;

DOI:10.1039/P19810001888

Reference yield:

(25R)-22,26-epiminocholesta-5,22(N)-diene-3β,16β-diol diacetate (30040-85-8) → pseudosolasodine diacetate (36506-65-7)

Guidance literature:

With methanol; potassium hydroxide;

DOI:10.1021/jo01362a047

Reference yield:

solasodine (126-17-0) → pseudosolasodine diacetate (36506-65-7)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid anhydride; acetic acid; zinc chloride

2: methanol; KOH-solution

With methanol; potassium hydroxide; acetic anhydride; acetic acid; zinc(II) chloride;

DOI:10.1021/jo01362a047

upstream raw materials:

acetic anhydride

solasodine

(25R)-22,26-epiminocholesta-5,22(N)-diene-3β,16β-diol diacetate

Downstream raw materials:

solasodine

Refernces