Droprenilamine

Base Information

• Chemical Name: Droprenilamine
• CAS No.: 57653-27-7
• Molecular Formula: C24H33 N
• Molecular Weight: 335.533
• UNII: 31IPX0ZD7R
• DSSTox Substance ID: DTXSID10866639
• Nikkaji Number: J14.533E
• Wikidata: Q27256057
• NCI Thesaurus Code: C65488
• ChEMBL ID: CHEMBL2106278
• Mol file: 57653-27-7.mol

Synonyms:droprenylamine;droprenylamine hydrochloride;MG 8926;N-(3,3-diphenylpropyl)-alpha-methyl-beta-cyclohexylethylamine

Chemical Property of Droprenilamine

Chemical Property:

• Vapor Pressure: 7.37E-09mmHg at 25°C
• Refractive Index: 1.54
• Boiling Point: 466°C at 760 mmHg
• PKA: 10.52±0.29(Predicted)
• Flash Point: 205.3°C
• PSA: 12.03000
• Density: 0.975g/cm³
• LogP: 6.54800
• XLogP3: 7.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 8
• Exact Mass: 335.261300057
• Heavy Atom Count: 25
• Complexity: 316

Purity/Quality:

95-99% ^*data from raw suppliers

DROPRENILAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CC1CCCCC1)NCCC(C2=CC=CC=C2)C3=CC=CC=C3
• Uses: Vasodilator (coronary).
• Therapeutic Function: Coronary vasodilator

Technology Process of Droprenilamine

There total 4 articles about Droprenilamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,3-diphenylacrylonitrile (3531-24-6) → droprenilamine (57653-27-7)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂, NH₃, NaOH / Raney-Ni / methanol

2: H₂ / PtO₂ / methanol

With sodium hydroxide; ammonia; hydrogen; platinum(IV) oxide; nickel; In methanol;

Reference yield:

Cyclohexylacetic acid (5292-21-7) → droprenilamine (57653-27-7)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether

2: H₂ / PtO₂ / methanol

With hydrogen; platinum(IV) oxide; In methanol; diethyl ether;

Reference yield:

3-hydroxy-3,3-diphenylpropanenitrile (3531-23-5) → droprenilamine (57653-27-7)

Guidance literature:

Multi-step reaction with 3 steps

1: POCl₃ / benzene

2: H₂, NH₃, NaOH / Raney-Ni / methanol

3: H₂ / PtO₂ / methanol

With sodium hydroxide; ammonia; hydrogen; trichlorophosphate; platinum(IV) oxide; nickel; In methanol; benzene;

upstream raw materials:

4-cyclohexyl-butan-2-one

3-diphenylpropyl amine

3,3-diphenylacrylonitrile

Cyclohexylacetic acid

Refernces