2-Fluoro-5-methoxybenzaldehyde

Base Information

• Chemical Name: 2-Fluoro-5-methoxybenzaldehyde
• CAS No.: 105728-90-3
• Molecular Formula: C8H7FO2
• Molecular Weight: 154.141
• Hs Code.: 29130000
• DSSTox Substance ID: DTXSID70370545
• Nikkaji Number: J1.641.193K
• Wikidata: Q72473923
• Mol file: 105728-90-3.mol

Synonyms:2-Fluoro-5-methoxybenzaldehyde;105728-90-3;6-Fluoro-m-anisaldehyde;Benzaldehyde, 2-fluoro-5-methoxy-;2-fluoro-5-methoxy-benzaldehyde;2-Fluoro-5-methoxy benzaldehyde;MFCD00070795;SCHEMBL387186;DTXSID70370545;DKIQXHIAEMGZGO-UHFFFAOYSA-N;2-fluoro-5-(methyloxy)benzaldehyde;CL8283;STL374069;2-Fluoro-5-methoxybenzaldehyde, 97%;AKOS006222736;AC-3839;AM61274;CS-W001188;DS-12023;SY004253;F0383;FT-0612359;EN300-108468;J-509445;Z1203161971

Chemical Property of 2-Fluoro-5-methoxybenzaldehyde

Chemical Property:

• Appearance/Colour: clear yellow liquid
• Vapor Pressure: 69.8mmHg at 25°C
• Melting Point: 48-50 °C
• Refractive Index: n20/D 1.532(lit.)
• Boiling Point: 245.6 °C at 760 mmHg
• Flash Point: 99.4 °C
• PSA: 26.30000
• Density: 1.192 g/cm³
• LogP: 1.64680
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Sensitive.: Air Sensitive
• Water Solubility.: Slightly soluble in water.
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 154.04300762
• Heavy Atom Count: 11
• Complexity: 138

Purity/Quality:

99% ^*data from raw suppliers

2-Fluoro-5-methoxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)F)C=O
• Uses: 2-Fluoro-5-methoxybenzaldehyde may be used in the synthesis of:5,10,15,20-tetrakis(2-fluoro-5-methoxyphenyl)porphyrinaryl(2-fluoro-5-methoxyphenyl)methanones5′-methoxy-4-nitro-2,2′,5-trifluorobenzophenone2-(2-fluoro-5-methoxybenzylidene)-1-(5-bromo-2-morpholinopyrimidin-4-yl) hydrazine

Technology Process of 2-Fluoro-5-methoxybenzaldehyde

There total 9 articles about 2-Fluoro-5-methoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

5-((tert-butyldimethylsilyl)oxy)-2-fluorobenzaldehyde (113984-67-1) + methyl iodide (74-88-4) → 2-fluoro-5-methoxybenzaldehyde (105728-90-3)

Guidance literature:

With potassium fluoride; In N,N-dimethyl-formamide; at 25 ℃; for 1h;

DOI:10.1016/S0040-4039(00)95560-6

Reference yield: 82.0%

4-fluoro-3-dibromomethylanisole (347176-55-0) → 2-fluoro-5-methoxybenzaldehyde (105728-90-3)

Guidance literature:

With sodium hydrogencarbonate; for 32h;

DOI:10.1016/S0968-0896(00)00286-8

Reference yield: 68.0%

2-(bromomethyl)-1-fluoro-4-methoxybenzene (91319-42-5) → 2-fluoro-5-methoxybenzaldehyde (105728-90-3)

Guidance literature:

With sodium carbonate; dimethyl sulfoxide; at 45 - 50 ℃; for 21h;

DOI:10.1021/ja00236a008

upstream raw materials:

N-Formylpiperidine

1-fluoro-4-methoxybenzene

2-(bromomethyl)-1-fluoro-4-methoxybenzene

N,N-dimethyl-formamide

Downstream raw materials:

5,10,15,20-tetrakis(2-fluoro-5-methoxyphenyl)porphyrin

2-chloro-6-fluoro-3-methoxy-benzaldehyde

4-(2-fluoro-5-methoxybenzyl)piperazine

5-methoxy-2-(phenoxy)benzaldehyde

Refernces

• 1、 -. "A preparation method of the compound [...] benzene substitution (by machine translation)". Paragraph 0024; 0025; 0026. . Retrieved 2018/03/26.
• 2、 -. "GPR40 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES". Page/Page column 83. . Retrieved 2017/03/17.