ETHYL-P-BIS(2-HYDROXYETHYL)AMINOBENZOATE

Base Information

• Chemical Name: ETHYL-P-BIS(2-HYDROXYETHYL)AMINOBENZOATE
• CAS No.: 15716-30-0
• Molecular Formula: C13H19 N O4
• Molecular Weight: 253.298
• Hs Code.: 2922509090
• Mol file: 15716-30-0.mol

Synonyms:Benzoicacid, p-[bis(2-hydroxyethyl)amino]-, ethyl ester (6CI,7CI,8CI); EthylN,N-bis(2-hydroxyethyl)-p-aminobenzoate; NSC 408500

Chemical Property of ETHYL-P-BIS(2-HYDROXYETHYL)AMINOBENZOATE

Chemical Property:

• PSA: 70.00000
• LogP: 0.65430

Purity/Quality:

99% ^*data from raw suppliers

ETHYL-PARA-BIS(2-HYDROXYETHYL)AMINOBENZOATE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL-P-BIS(2-HYDROXYETHYL)AMINOBENZOATE

There total 7 articles about ETHYL-P-BIS(2-HYDROXYETHYL)AMINOBENZOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

oxirane (75-21-8,99932-75-9) + p-aminoethylbenzoate (94-09-7) → ethyl 4-benzoate (15716-30-0)

Guidance literature:

With formic acid; In water; at 20 ℃; for 24h;

DOI:10.1021/ml500141f

Reference yield:

4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → ethyl 4-benzoate (15716-30-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 5 h / Reflux

2: formic acid / water / 24 h / 20 °C

With formic acid; sulfuric acid; In water;

DOI:10.1021/ml500141f

Reference yield:

oxirane (75-21-8,99932-75-9) + p-aminoethylbenzoate (94-09-7) → ethyl 4-benzoate (15716-30-0) + ethyl 4-benzoate (55966-68-2)

Guidance literature:

With water; acetic acid; acetone;

upstream raw materials:

oxirane

p-aminoethylbenzoate

4-amino-benzoic acid

2-chloro-ethanol

Downstream raw materials:

4-{bis(2-chloroethyl)amino}benzoic acid

Refernces

• 1、 Chen, Zhe,Guo, Lina,Li, Chuan,Ma, Liwei,Ma, Yukun,Tian, Yanzhao,Wang, Wenbao,Wang, Xiaobo,Wang, Xiaoli,Ye, Jin,Zhang, Jinling. "Novel diosgenin–amino acid–benzoic acid mustard trihybrids exert antitumor effects via cell cycle arrest and apoptosis". . . Retrieved 2021/12/10.
• 2、 -. "A class β . Preparation method and anti-tumor application". Paragraph 0027-0028; 0031. . Retrieved 2021/09/22.