4,6-Dihydroxy-2-phenylpyrimidine

Base Information

• Chemical Name: 4,6-Dihydroxy-2-phenylpyrimidine
• CAS No.: 13566-71-7
• Molecular Formula: C10H8N2O2
• Molecular Weight: 188.186
• Hs Code.: 2933599090
• Mol file: 13566-71-7.mol

Synonyms:4(1H)-Pyrimidinone,6-hydroxy-2-phenyl- (8CI,9CI);4,6-Pyrimidinediol, 2-phenyl- (6CI,7CI);2-Phenyl-4,6-dihydroxypyrimidine;2-Phenyl-4,6-pyrimidinediol;4,6-Dihydroxy-2-phenylpyrimidine;6-Oxo-4-hydroxy-2-phenyl-3,6-dihydropyrimidine;NSC 48054;

Chemical Property of 4,6-Dihydroxy-2-phenylpyrimidine

Chemical Property:

• Vapor Pressure: 0.00104mmHg at 25°C
• Melting Point: 325-330 °C
• Refractive Index: 1.651
• Boiling Point: 292.6 °C at 760 mmHg
• PKA: 5.04±0.10(Predicted)
• Flash Point: 130.8 °C
• PSA: 66.24000
• Density: 1.33 g/cm³
• LogP: 1.55480
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-Phenyl-pyrimidine-4,6-diol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,6-Dihydroxy-2-phenylpyrimidine

There total 13 articles about 4,6-Dihydroxy-2-phenylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

benzamidine monohydrochloride (1670-14-0) + malonic acid dimethyl ester (108-59-8) → 2-Phenyl-4,6-dihydroxy-pyrimidine (13566-71-7)

Guidance literature:

benzamidine monohydrochloride; malonic acid dimethyl ester; With sodium methylate; In methanol; at 55 ℃; for 2h;

With acetic acid; In methanol; water; for 0.5h;

Reference yield: 80.0%

benzimidamide hydrochloride + malonic acid dimethyl ester (108-59-8) → 2-Phenyl-4,6-dihydroxy-pyrimidine (13566-71-7)

Guidance literature:

With sodium methylate; sodium chloride; In methanol; at 55 ℃; for 2h;

Reference yield: 73.6%

benzamidine monohydrochloride (1670-14-0) + diethyl malonate (105-53-3) → 2-Phenyl-4,6-dihydroxy-pyrimidine (13566-71-7)

Guidance literature:

With sodium ethanolate; In ethanol; for 3h; Heating;

upstream raw materials:

benzamidine monohydrochloride

diethyl malonate

benzamidin

malonic acid dimethyl ester

Downstream raw materials:

fenclorim

2-Phenyl-5-nitro-4,6-dihydroxy-pyrimidine

2-Phenyl-5-nitro-4,6-dichloro-pyrimidine

4⁽⁶⁾-Benzylamino-6⁽⁴⁾-chloro-2-phenylpyrimidine

Refernces

• 1、 Napiera?a, Sergiusz,Kubicki, Maciej,Patroniak, Violetta,Wa??sa-Chorab, Monika. "Electropolymerization of [2 × 2] grid-type cobalt(II) complex with thiophene substituted dihydrazone ligand". . . Retrieved 2021.
• 2、 Holub, Jan,Santoro, Antonio,Lehn, Jean-Marie. "Electronic absorption and emission properties of bishydrazone [2?×?2] metallosupramolecular grid-type architectures". . p. 223 - 231. Retrieved 2019/06/07.