1,2,5-Trihydroxypentane

Base Information

• Chemical Name: 1,2,5-Trihydroxypentane
• CAS No.: 5470-86-0
• Molecular Formula: C11H18O6
• Molecular Weight: 246.26
• Hs Code.: 2915390090
• Mol file: 5470-86-0.mol

Synonyms:1,2,5-Triacetoxy-pentan;1,5-diacetyloxypentan-2-yl acetate;pentane-1,2,5-triyl triacetate;1,2,5-triacetoxypentane;4,5-diacetyloxypentyl ethanoate;

Chemical Property of 1,2,5-Trihydroxypentane

Chemical Property:

• Vapor Pressure: 0.000465mmHg at 25°C
• Boiling Point: 314.5°C at 760 mmHg
• Flash Point: 134.7°C
• PSA: 78.90000
• Density: 1.114g/cm³
• LogP: 0.82450

Purity/Quality:

99%min ^*data from raw suppliers

1,2,5-TRIACETOXYPENTANE AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2,5-Trihydroxypentane

There total 11 articles about 1,2,5-Trihydroxypentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

Tetrahydrofurfuryl alcohol (97-99-4) + acetic anhydride (108-24-7) → 1,2,5-triacetoxypentane (5470-86-0)

Guidance literature:

With sulfuric acid; at 20 ℃; for 20h;

DOI:10.1002/jhet.5570370555

Reference yield:

Tetrahydrofurfuryl alcohol (97-99-4) + acetyl chloride (75-36-5) → 1,2,5-triacetoxypentane (5470-86-0)

Guidance literature:

With zinc(II) chloride;

Reference yield:

L-hydroxyglutaric acid (13095-48-2,636-67-9) → (S)-1,2,5-triacetoxy-pentane (5470-86-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen chloride

2: lithium alanate; diethyl ether / anschliessend Behandeln mit Acetanhydrid und Pyridin bzw. mit Acetanhydrid und Natriumacetat

With hydrogenchloride; lithium aluminium tetrahydride; diethyl ether;

upstream raw materials:

(S)-dimethyl 2-hydroxypentanedioate

(–)-(S)-diethyl 2-hydroxyglutarate

L-hydroxyglutaric acid

Tetrahydrofurfuryl alcohol

Downstream raw materials:

1-(pent-4-en-1-yl)-1H-pyrrole

5-N-pyrrolylpentane-1,2-diol 1-p-toluenesulfonate

rac-2,2-dimethyl-4-(3'-hydroxypropyl)-1,3-dioxolan toluene-p-sulphonate

2,2-dimethyl-4-(3-hydroxypropyl)-1,3-dioxolane

Refernces

• 1、 Gage, Jennifer L.,Branchaud, Bruce P.. "A synthesis of (-)-tashiromine and formal synthesis of (+)-tashiromine utilizing a highly enantioselective pyrrole/cobaloxime π-cation cyclization". . p. 7007 - 7010. Retrieved 2007/10/03.