GANODERIC ACID A

Base Information

• Chemical Name: GANODERIC ACID A
• CAS No.: 81907-62-2
• Molecular Formula: C30H42O7
• Molecular Weight: 514.65
• Hs Code.: 29189900
• Metabolomics Workbench ID: 72204
• Pharos Ligand ID: BLTG7FMBHLBM
• Wikidata: Q103818798
• Wikipedia: Ganoderic_acid
• Mol file: 81907-62-2.mol

Synonyms:Ganodericacid A;(7beta,15alpha,25R)-7,15-dihydroxy-3,11,23-trioxolanost-8-en-26-oic acid;Lanost-8-en-26-oic acid, 7,15-dihydroxy-3,11,23-trioxo-, (7β,15α,25R)-;

Chemical Property of GANODERIC ACID A

Chemical Property:

• Vapor Pressure: 4.89E-22mmHg at 25°C
• Melting Point: 118～123℃
• Refractive Index: 1.564
• Boiling Point: 690.1 °C at 760 mmHg
• PKA: 4.78±0.23(Predicted)
• Flash Point: 385.1 °C
• PSA: 128.97000
• Density: 1.22 g/cm³
• LogP: 4.05160
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• Solubility.: Chloroform (Slightly, Sonicated), Methanol (Slightly)
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 6
• Exact Mass: 516.30870374
• Heavy Atom Count: 37
• Complexity: 1070

Purity/Quality:

Ganoderic Acid A ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CC(=O)CC(C)C(=O)O)C1CC(C2(C1(CC(=O)C3=C2C(CC4C3(CCC(=O)C4(C)C)C)O)C)C)O
• Description: Ganoderic acid A is a triterpene that has been found in Ganoderma and has diverse biological activities. It reduces cell viability, expression of superoxide dismutase 1 (SOD1), SOD2, and SOD3, and production of reactive oxygen species (ROS) in PC3 prostate cancer cells. Ganoderic acid A (2-100 μg/ml) reduces hypoxia-induced apoptosis in H9c2 cardiomyocytes. It inhibits LPS-induced activation of NF-κB, release of TNF-α, IL-1β, and IL-6, and mitochondrial activity in primary mouse cortical microglia. Ganoderic acid A (20 and 40 mg/kg) reduces lung myeloperoxidase (MPO) activity, neutrophil infiltration, and NF-κB signaling, as well as bronchoalveolar lavage fluid (BALF) levels of TNF-α, IL-1β, and IL-6 in a mouse model of LPS-induced lung injury. It also reduces weight gain and hepatic lipid accumulation and improves insulin sensitivity in a mouse model of high-fat diet-induced obesity.
• Uses: Ganoderic Acid A, is a new lanostanoid triterpene extracted from the fruit bodies of Ganoderma Lucidum mushroom. these compounds are shown to possess many therapeutic properties. They can be used as anti-virus, anti-inflammation, anti-tumor, immunity-promoting, anti-diabetic, etc.