ACETALDEHYDE-2,2,2-D3

Base Information

• Chemical Name: ACETALDEHYDE-2,2,2-D3
• CAS No.: 19901-15-6
• Molecular Formula: C2H D3 O
• Molecular Weight: 47.0293
• Mol file: 19901-15-6.mol

Synonyms:2,2,2-Trideuteroacetaldehyde

Chemical Property of ACETALDEHYDE-2,2,2-D3

Chemical Property:

• Vapor Pressure: 965mmHg at 25°C
• Melting Point: −125 °C(lit.)
• Refractive Index: n20/D 1.332(lit.)
• Boiling Point: 21 °C(lit.)
• Flash Point: °C
• PSA: 17.07000
• Density: 0.799g/cm³
• LogP: 0.20520
• Storage Temp.: 0-6°C

Purity/Quality:

99%, ^*data from raw suppliers

Acetaldehyde-d3 ^*data from reagent suppliers

Safty Information:

• Hazard Codes: F+,Xn
• Statements: 12-36/37-40
• Safety Statements: 16-33-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: ACETALDEHYDE-2,2,2-D3 is used as a derivatizing agent in the measurement of endogenous epinephrine and norepinephrine in human plasma. It is also used to label the amine groups on biogenic monoamine neur otransmitters for simultaneous panel determination.

Technology Process of ACETALDEHYDE-2,2,2-D3

There total 9 articles about ACETALDEHYDE-2,2,2-D3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

[D3]acetonitrile (2206-26-0) + [(Ph2PC6H4CH2S)2(C2H4)Ni-COCH3]BPh4 → ethanol-d6 (1516-08-1) + 2,2,2-trideuteroethanol (1759-87-1) + acetaldehyde-2,2,2-d3 (19901-15-6) + ethanol-d3 (22544-42-9) + ((Ph2PC6H4CH2S)2(C2H4))Ni + acetaldehyde (75-07-0,9002-91-9)

Guidance literature:

With tetrabutylammonium borohydride; for 0.0833333h; Inert atmosphere; Schlenk technique; Glovebox;

DOI:10.1021/acs.organomet.7b00472

Reference yield: 43.0%

acetaldehyde (75-07-0,9002-91-9) → acetaldehyde-2,2,2-d3 (19901-15-6)

Guidance literature:

With water-d2; In pyridine; at 80 ℃; for 36h;

Reference yield:

1,1,1,3,3,3-hexadeuteriopropane (2875-96-9) → [(2)H6]acetone (666-52-4) + acetaldehyde-2,2,2-d3 (19901-15-6) + propene-1,1,3,3,3-d5 (13275-25-7,1560-60-7)

Guidance literature:

With oxygen; at 353.9 ℃; Kinetics;

DOI:10.1246/bcsj.60.3739

upstream raw materials:

1,1,1,3,3,3-hexadeuteriopropane

d⁽⁴⁾-methanol

carbon monoxide

2,2,2-trideuteroethanol

Downstream raw materials:

<1,2,2,2-D4>Ethanol

Refernces

• 1、 Baldwin,Pudussery. "". . p. 408. Retrieved 1968.
• 2、 Pichat, Pierre,Mozzanega, Marie-Noelle,Courbon, Henri. "Investigation of the Mechanism of Photocatalytic Alcohol Dehydrogenation over Pt/TiO2 using Poisons and Labelled Ethanol". . p. 697 - 704. Retrieved 1987.
• 3、 Zhang, Ailing,Raje, Sakthi,Liu, Jianguo,Li, Xiaoyan,Angamuthu, Raja,Tung, Chen-Ho,Wang, Wenguang. "Nickel-Mediated Stepwise Transformation of CO to Acetaldehyde and Ethanol". . p. 3135 - 3141. Retrieved 2017/09/05.