Technology Process of Spirapril
There total 11 articles about Spirapril which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 6.8 g / SOCl2 / 20 h / Heating
2: 3.86 g / p-toluenesulfonic acid / acetic acid / 44 h / Heating
3: 6.3 g / 20percent HBr/glacial acetic acid / 2 h / Ambient temperature
4: 3.64 g / 2.5 N aq. NaOH / methanol / 18 h / Ambient temperature
5: 1.) N,N-disuccinimidyl carbonate, pyridine, 2.) NEt3 / 1.) CH3CN, RT, 44 h, 2.) CH3CN, H2O, RT
With
pyridine; sodium hydroxide; thionyl chloride; di(succinimido) carbonate; hydrogen bromide; toluene-4-sulfonic acid; acetic acid; triethylamine;
In
methanol; acetic acid;
DOI:10.1021/jm00127a033
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1->3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / 18 h / Ambient temperature
2: 4.6 g / NEt3 / dimethylformamide / Ambient temperature
With
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
N,N-dimethyl-formamide;
DOI:10.1021/jm00127a033
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 3.86 g / p-toluenesulfonic acid / acetic acid / 44 h / Heating
2: 6.3 g / 20percent HBr/glacial acetic acid / 2 h / Ambient temperature
3: 3.64 g / 2.5 N aq. NaOH / methanol / 18 h / Ambient temperature
4: 1.) N,N-disuccinimidyl carbonate, pyridine, 2.) NEt3 / 1.) CH3CN, RT, 44 h, 2.) CH3CN, H2O, RT
With
pyridine; sodium hydroxide; di(succinimido) carbonate; hydrogen bromide; toluene-4-sulfonic acid; acetic acid; triethylamine;
In
methanol; acetic acid;
DOI:10.1021/jm00127a033
