4-Aminomethyltetrahydropyran

Base Information Edit

Chemical Name:4-Aminomethyltetrahydropyran
CAS No.:130290-79-8
Molecular Formula:C6H13NO
Molecular Weight:115.175
Hs Code.:29329990
European Community (EC) Number:638-888-2
DSSTox Substance ID:DTXSID70378283
Nikkaji Number:J2.470.375D
Wikidata:Q72439693
Mol file:130290-79-8.mol

Synonyms:4-aminomethyltetrahydropyran;130290-79-8;(Tetrahydro-2H-pyran-4-yl)methanamine;Oxan-4-ylmethanamine;4-(aminomethyl)tetrahydro-2h-pyran;4-(Aminomethyl)tetrahydropyran;2H-PYRAN-4-METHANAMINE, TETRAHYDRO-;(oxan-4-yl)methanamine;c-(tetrahydro-pyran-4-yl)-methylamine;(Tetrahydro-2H-pyran-4-yl)methylamine;C-(Tetrahydropyran-4-yl)methylamine;tetrahydro-2H-pyran-4-ylmethylamine;MFCD02179435;1-(tetrahydro-2H-pyran-4-yl)methanamine;TETRAHYDRO-2H-PYRAN-4-METHANAMINE;1-tetrahydro-2H-pyran-4-ylmethanamine;(tetrahydropyran-4-yl)methylamine;(tetrahydro-2h-pyran-4-yl) methanamine;4-(AMinoMethyl)tetrahydro;4-Tetrahydropyranmethylamine;1-(TETRAHYDRO-2H-PYRAN-4-YL)METHYLAMINE;4-aminomethyl-tetrahydropyran;4-aminomethyltetra-hydropyran;SCHEMBL20567;4-Aminomethyl tetrahydropyran;tetrahydropyran-4-ylmethylamine;tetrahydro-pyran-4-ylmethylamine;tetrahydropyran-4-ylmethyl amine;DTXSID70378283;IPBPLHNLRKRLPJ-UHFFFAOYSA-N;(tetrahydro-pyran-4-yl)methylamine;BCP04866;1-(4-tetrahydropyranyl)-methylamine;1-(tetrahydropyran-4-yl)methylamine;AB1593;STK360701;(tetrahydro-2h-pyran-4-ylmethyl)amine;AKOS000303145;CS-W008973;PB27569;PS-3295;(tetrahydro-2h-pyran-4-yl)methan-amine;(tetrahydro-2H-pyran-4-yl)methaneamine;4-aminomethyltetrahydropyran, AldrichCPR;1-tetrahydro-2H-pyran-4-ylmethane-amine;[(Tetrahydro-2H-pyran-4-yl)methyl]amine;SY001214;AM20080212;BB 0237243;FT-0601976;EN300-57193;4-(Aminomethyl)-2H-3,4,5,6-tetrahydropyran;Q-101921;F2191-0294;Z440605454

Suppliers and Price of 4-Aminomethyltetrahydropyran

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Aminomethyltetrahydropyran
2.5 g
$ 220.00

TCI Chemical
4-Aminomethyltetrahydropyran >98.0%(GC)(T)
1g
$ 73.00

TCI Chemical
4-Aminomethyltetrahydropyran >98.0%(GC)(T)
5g
$ 236.00

Matrix Scientific
C-(Tetrahydro-pyran-4-yl)-methylamine
100g
$ 143.00

Matrix Scientific
C-(Tetrahydro-pyran-4-yl)-methylamine
25g
$ 49.00

Frontier Specialty Chemicals
4-(Aminomethyl)tetrahydropyran 97%
1g
$ 81.00

Frontier Specialty Chemicals
4-(Aminomethyl)tetrahydropyran 97%
500mg
$ 45.00

Crysdot
(Tetrahydro-2H-pyran-4-yl)methanamine 97+%
25g
$ 85.00

Atlantic Research Chemicals
4-Aminomethyltetrahydropyran 95%
10gm:
$ 24.74

American Custom Chemicals Corporation
4-AMINOMETHYLTETRAHYDROPYRAN 95.00%
10G
$ 1228.92

Total 107 raw suppliers

Chemical Property of 4-Aminomethyltetrahydropyran Edit

Chemical Property:

Appearance/Colour:clear colorless liquid
Vapor Pressure:0.912mmHg at 25°C
Refractive Index:1.4630-1.4670
Boiling Point:180.1 °C at 760 mmHg
PKA:10.01±0.29(Predicted)
Flash Point:64.9 °C
PSA：35.25000
Density:0.942 g/cm³
LogP:1.07200
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
XLogP3:-0.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:115.099714038
Heavy Atom Count:8
Complexity:59.5

Purity/Quality:

99.0% min ^*data from raw suppliers

4-Aminomethyltetrahydropyran ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi, C
Hazard Codes:Xi,C,Xn
Statements: 34-41-37/38-22
Safety Statements: 26-36/37/39-45-39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1COCCC1CN
Uses 4-Aminomethyltetrahydropyran is a reagent that is used in core modification in discovery of CC214-2 which is an orally available , selective inhibitor of mTOR kinase. 4-Aminomethyltetrahydropyran is also used as a reagent in the development of pyrazoloquinolines as PDE10A inhibitor for the treatment of schizophrenia.

Technology Process of 4-Aminomethyltetrahydropyran

There total 7 articles about 4-Aminomethyltetrahydropyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.3%

: 4295-99-2
tetrahydro-2H-pyran-4-carbonitrile

: 130290-79-8
4-tetrahydropyranmethylamine

Guidance literature:: With ammonia; hydrogen; Raney nickel; In methanol; at 45 - 60 ℃; for 5 - 17h; under 3825.38 - 4575.46 Torr; Product distribution / selectivity;