Acetamide, N-[4-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)phenyl]-

Base Information

• Chemical Name: Acetamide, N-[4-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)phenyl]-
• CAS No.: 5702-75-0
• Molecular Formula: C12H10N2O3
• Molecular Weight: 230.223
• Hs Code.: 2925190090
• Mol file: 5702-75-0.mol

Synonyms:Acetamide, N-[4-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)phenyl]-;N-[4-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)phenyl]acetamide;

Chemical Property of Acetamide, N-[4-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)phenyl]-

Chemical Property:

• Vapor Pressure: 8.97E-10mmHg at 25°C
• Melting Point: 166 °C
• Refractive Index: 1.664
• Boiling Point: 490.7 °C at 760 mmHg
• PKA: 14.45±0.70(Predicted)
• Flash Point: 250.5 °C
• PSA: 66.48000
• Density: 1.409 g/cm³
• LogP: 1.21240

Purity/Quality:

98%min ^*data from raw suppliers

N-[4-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)phenyl]acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetamide, N-[4-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)phenyl]-

There total 4 articles about Acetamide, N-[4-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

acetic anhydride (108-24-7) + (2Z)-4-[(4-aminophenyl)amino]-4-oxo-2-butenoic acid (71603-06-0) → N-(4-acetylamidophenyl)maleimide (5702-75-0)

Guidance literature:

With sodium acetate; for 1h;

Reference yield:

C12H12N2O4 → N-(4-acetylamidophenyl)maleimide (5702-75-0)

Guidance literature:

With phosphorus pentoxide; sulfuric acid; In N,N-dimethyl-formamide; at 60 - 65 ℃;

DOI:10.14233/ajchem.2016.19769

Reference yield:

N-acetyl-p-phenylenediamine (122-80-5) → N-(4-acetylamidophenyl)maleimide (5702-75-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 4 h

2: sulfuric acid; phosphorus pentoxide / N,N-dimethyl-formamide / 60 - 65 °C

With phosphorus pentoxide; sulfuric acid; In N,N-dimethyl-formamide;

DOI:10.14233/ajchem.2016.19769

upstream raw materials:

N-(4-acetylamino-phenyl)-maleamic acid

acetic anhydride

(2Z)-4-[(4-aminophenyl)amino]-4-oxo-2-butenoic acid

N-acetyl-p-phenylenediamine

Refernces

• 1、 Fruk, Ljiljana,Graham, Duncan. "The electronic effects on the formation of N-aryl-maleimides and isomaleimides". . p. 2305 - 2313. Retrieved 2007/10/03.