Acetamide, N-(2,4-dibromophenyl)-

Base Information

• Chemical Name: Acetamide, N-(2,4-dibromophenyl)-
• CAS No.: 23373-04-8
• Molecular Formula: C8H7Br2NO
• Molecular Weight: 292.958
• Hs Code.: 2924299090
• European Community (EC) Number: 607-224-3
• NSC Number: 526453
• DSSTox Substance ID: DTXSID60177924
• Nikkaji Number: J88.146E
• Wikidata: Q83048267
• Mol file: 23373-04-8.mol

Synonyms:23373-04-8;N-(2,4-dibromophenyl)acetamide;Acetamide, N-(2,4-dibromophenyl)-;2',4'-Dibromoacetanilide;2,4-Dibromoacetanilide;Acetamide,N-(2,4-dibromophenyl)-;NSC526453;2,4-dibromo-acetanilide;SCHEMBL1801329;DTXSID60177924;AKOS003849541;NSC 526453;NSC-526453;FT-0609983;A856059;AE-641/01922038

Chemical Property of Acetamide, N-(2,4-dibromophenyl)-

Chemical Property:

• Vapor Pressure: 3.55E-06mmHg at 25°C
• Melting Point: 145.400078125 °C
• Refractive Index: 1.641
• Boiling Point: 386.4 °C at 760 mmHg
• PKA: 13.32±0.70(Predicted)
• Flash Point: 187.5 °C
• PSA: 29.10000
• Density: 1.891 g/cm³
• LogP: 3.24300
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 292.88739
• Heavy Atom Count: 12
• Complexity: 174

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(=O)NC1=C(C=C(C=C1)Br)Br

Technology Process of Acetamide, N-(2,4-dibromophenyl)-

There total 30 articles about Acetamide, N-(2,4-dibromophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-bromoacetanilide (103-88-8) → 2',4'-dibromoacetanilide (23373-04-8)

Guidance literature:

With N-Bromosuccinimide; In acetonitrile; for 2h; regioselective reaction; Irradiation;

DOI:10.1002/ejoc.201801097

Reference yield: 95.0%

Acetanilid (103-84-4) → 2',4'-dibromoacetanilide (23373-04-8)

Guidance literature:

With N-Bromosuccinimide; tetrachlorosilane; In dichloromethane; at 25 ℃; for 1.5h;

DOI:10.1080/10426500600574838

Reference yield: 78.0%

Acetanilid (103-84-4) → 4-bromoacetanilide (103-88-8) + 2',4'-dibromoacetanilide (23373-04-8)

Guidance literature:

With iodine pentoxide; potassium bromide; In water; at 20 ℃; for 20h; regioselective reaction;

DOI:10.1080/00397911.2013.796523

upstream raw materials:

N-acetyl-2-bromoaniline

4-bromoacetanilide

4,N-dibromoacetanilide

N-(2,4-dibromo-phenyl)-malonamic acid

Downstream raw materials:

acetic acid-(2,4-dibromo-6-nitro-anilide)

3,5-dibromo-1,2-phenylendiamine

5-bromo-2-methyl-1-phenyl-1H-benzo[d]imidazole

5-bromo-2-methylbenzimidazole

Refernces

• 1、 Singh, Harshvardhan,Sen, Chiranjit,Sahoo, Tapan,Ghosh, Subhash Chandra. "A Visible Light-Mediated Regioselective Halogenation of Anilides and Quinolines by Using a Heterogeneous Cu-MnO Catalyst". . p. 4748 - 4753. Retrieved 2018/09/06.
• 2、 Tian, Chao,Yao, Xu,Ji, Weizhe,Wang, Qian,An, Guanghui,Li, Guangming. "A para-C–H Functionalization of Aniline Derivatives via In situ Generated Bulky Hypervalent Iodinium Reagents". supporting information. p. 5972 - 5979. Retrieved 2018/11/23.