5-IODO-2',3'-DIDEOXYURIDINE

Base Information

• Chemical Name: 5-IODO-2',3'-DIDEOXYURIDINE
• CAS No.: 105784-83-6
• Molecular Formula: C9H11 I N2 O4
• Molecular Weight: 338.102
• Hs Code.: 29349990
• Mol file: 105784-83-6.mol

Synonyms:5-Iodo-2',3'-dideoxyuridine

Chemical Property of 5-IODO-2',3'-DIDEOXYURIDINE

Chemical Property:

• Melting Point: 176 °C (dec.)(lit.)
• Boiling Point: °Cat760mmHg
• PKA: 7.94±0.10(Predicted)
• Flash Point: °C
• PSA: 84.32000
• Density: 2.02g/cm³
• LogP: -0.18890
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2'',3''-Dideoxy-5-iodouridine ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2′,3′-Dideoxy-5-iodouridine (5-Iodo-2′,3′-dideoxyuridine) was used in preparation of fluorescence-tagged chain-terminating reagents, T-526, for rapid DNA sequencing.

Technology Process of 5-IODO-2',3'-DIDEOXYURIDINE

There total 7 articles about 5-IODO-2',3'-DIDEOXYURIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2',3'-Dideoxyuridine (5983-09-5,153547-98-9) → 5-Iodo-2',3'-dideoxyuridine (105784-83-6)

Guidance literature:

With sodium azide; Iodine monochloride; In acetonitrile; at 25 ℃; for 24h;

DOI:10.1021/jm070391t

Reference yield: 80.0%

2',3'-dideoxy-5-iodo-6-methoxyuridine (681821-72-7) → 5-Iodo-2',3'-dideoxyuridine (105784-83-6)

Guidance literature:

With triethylamine; In acetonitrile; for 2h; Heating;

DOI:10.1021/jm030857h

Reference yield: 31.0%

2',3'-Dideoxyuridine (5983-09-5) → 2',3'-dideoxy-5-iodouridine (105784-83-6)

Guidance literature:

With iodine; iodic acid; In tetrachloromethane; water; acetic acid; at 45 ℃; for 2h;

DOI:10.1021/jm00385a033

upstream raw materials:

2',3'-Dideoxyuridine

2',3'-dideoxy-5-iodo-6-methoxyuridine

2'-deoxyuridine

1-(3,5-anhydro-2-deoxy-β-D-threo-pentofuranosyl)uracil

Downstream raw materials:

3'-O-acetyl-5-(2-(4-ethynylphenyl)ethynyl)-2'-deoxycytidine

3'-O-acetyl-5-(2-(4-ethynylphenyl)ethynyl)-2'-deoxyuridine

2,2,2-Trifluoro-N-{3-[1-((S)-5-hydroxymethyl-tetrahydro-furan-2-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-prop-2-ynyl}-acetamide

5-(3-Trifluoroacetamido-1-propynyl)-2',3'-dideoxy-uridine

Refernces

• 1、 McGuigan, Christopher,Pathirana, Ranjith N.,Snoeck, Robert,Andrei, Graciela,De Clercq, Erik,Balzarini, Jan. "Discovery of a New Family of Inhibitors of Human Cytomegalovirus (HCMV) Based upon Lipophilic Alkyl Furano Pyrimidine Dideoxy Nucleosides: Action via a Novel Non-Nucleosidic Mechanism". . p. 1847 - 1851. Retrieved 2007/10/03.
• 2、 -. "Alkynylamino-nucleotides". . . Retrieved 2008/06/13.