1-Fluoro-3-iodo-5-nitrobenzene

Base Information

• Chemical Name: 1-Fluoro-3-iodo-5-nitrobenzene
• CAS No.: 3819-88-3
• Molecular Formula: C6H3FINO2
• Molecular Weight: 266.998
• Hs Code.: 29049090
• Mol file: 3819-88-3.mol

Synonyms:3-Fluoro-5-iodo-1-nitrobenzene;3-Nitro-5-fluoroiodobenzene;NSC 88609;

Chemical Property of 1-Fluoro-3-iodo-5-nitrobenzene

Chemical Property:

• Vapor Pressure: 0.00753mmHg at 25°C
• Melting Point: 77-79 °C(lit.)
• Refractive Index: 1.635
• Boiling Point: 277.7±20.0 °C at 760 mmHg
• Flash Point: 121.7±21.8 °C
• PSA: 45.82000
• Density: 2.1±0.1 g/cm³
• LogP: 2.86170
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Sensitive.: Light Sensitive
• Solubility.: soluble in Methanol

Purity/Quality:

98% ^*data from raw suppliers

1-Fluoro-3-iodo-5-nitrobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 1-Fluoro-3-iodo-5-nitrobenzene may be used in chemical synthesis.

Technology Process of 1-Fluoro-3-iodo-5-nitrobenzene

There total 5 articles about 1-Fluoro-3-iodo-5-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

4-fluoro-2-nitrobenzoic acid (394-01-4) → 1-fluoro-3-iodo-5-nitrobenzene (3819-88-3)

Guidance literature:

With copper(I) oxide; potassium phosphate; bismuth (III) nitrate pentahydrate; oxygen; palladium diacetate; sodium iodide; In dimethyl sulfoxide; at 170 ℃; for 10h; regioselective reaction; Schlenk technique; Green chemistry;

DOI:10.1021/acs.orglett.9b00460

Reference yield:

deoxygenated ortho-dichlorobenzene + 3-nitro-5-iodoaniline (10394-64-6) → 1-Fluoro-3-nitroiodobenzene (122455-36-1) + 1-fluoro-3-iodo-5-nitrobenzene (3819-88-3)

Guidance literature:

With nitrogen; nitrosonium tetrafluoroborate; In dichloromethane;

Reference yield:

deoxygenated ortho-dichlorobenzene + 3-nitro-5-iodoaniline (10394-64-6) → 1-fluoro-3-iodo-5-nitrobenzene (3819-88-3)

Guidance literature:

With nitrogen; nitrosonium tetrafluoroborate; In dichloromethane;

upstream raw materials:

meta-dinitrobenzene

3-nitro-5-iodoaniline

4-fluoro-2-nitrobenzoic acid

Downstream raw materials:

3-fluoro-5-nitrobenzonitrile

3-fluoro-5-piperazin-1-yl-benzonitrile

1-(3-fluoro-5-iodophenyl)piperazine

3-fluoro-5-{4-[3-(5-methyl-1-pyrimidin-2-yl-1H-pyrazol-4-yl)-3-oxo-propyl]-piperazin-1-yl}-benzonitrile

Refernces

• 1、 -. "Method for synthesizing m-iodonitrobenzene compound". Paragraph 0057-0058. . Retrieved 2018/03/24.
• 2、 -. "Steroid receptor modulator compounds and methods". . . Retrieved 2008/06/13.