(2R)-2-azaniumyl-4-hydroxybutanoate

Base Information

• Chemical Name: (2R)-2-azaniumyl-4-hydroxybutanoate
• CAS No.: 6027-21-0
• Molecular Formula: C4H9 N O3
• Molecular Weight: 119.12
• Hs Code.: 2922509090
• Mol file: 6027-21-0.mol

Synonyms:(2R)-2-azaniumyl-4-hydroxybutanoate;D-homoserine zwitterion;CHEBI:143081;A813596;(2R)-2-azaniumyl-4-hydroxy-butanoate;DL-Homoserine

Chemical Property of (2R)-2-azaniumyl-4-hydroxybutanoate

Chemical Property:

• Appearance/Colour: White or almost white crystalline powder
• Melting Point: 205 °C (dec.)(lit.)
• Refractive Index: 8.0 ° (C=2, H2O)
• Boiling Point: 368.7 °C at 760 mmHg
• PKA: 2.21±0.10(Predicted)
• Flash Point: 176.8 °C
• PSA: 83.55000
• Density: 1.312 g/cm³
• LogP: -0.51900
• Storage Temp.: Store at 0-5°C
• Water Solubility.: Soluble
• XLogP3: -3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 119.058243149
• Heavy Atom Count: 8
• Complexity: 77.8

Purity/Quality:

99% ^*data from raw suppliers

D-Homoserine ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C(CO)C(C(=O)[O-])[NH3+]
• Isomeric SMILES: C(CO)[C@H](C(=O)[O-])[NH3+]

Technology Process of (2R)-2-azaniumyl-4-hydroxybutanoate

There total 14 articles about (2R)-2-azaniumyl-4-hydroxybutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(2R)-methionine methysulfonium iodide (3493-10-5) → D-homoserine (6027-21-0,119736-88-8)

Guidance literature:

With water; sodium hydrogencarbonate; pH=2 - 5; Reflux;

Reference yield: 100.0%

→ D-homoserine (6027-21-0,119736-88-8)

Guidance literature:

Reference yield: 84.0%

C29H31N3NiO4 → D-homoserine (6027-21-0,119736-88-8)

Guidance literature:

C₂₉H₃₁N₃NiO₄; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; at 70 ℃;

In water;

DOI:10.1039/c3ob40541a

upstream raw materials:

D-homoserine lactone

D-methionine

(R)-(+)-α-amino-γ-butyrolactone hydrochloride

3-amino-3-furan-2-ylpropan-1-ol

Downstream raw materials:

C₂₈H₃₀N₂O₇

(2R)-benzyl 2-(N-(9-fluorenylmethoxycarbonyl)amino)-4-hydroxybutanoate

C₁₈H₂₆N₂O₆

N-[(phenylmethoxy)carbonyl]-D-homoserine

Refernces

• 1、 Prasad, Vysakh Pushpa,Wagner, Stefan,Keul, Petra,Hermann, Sven,Levkau, Bodo,Sch?fers, Michael,Haufe, Günter. "Synthesis of fluorinated analogues of sphingosine-1-phosphate antagonists as potential radiotracers for molecular imaging using positron emission tomography". . p. 5168 - 5181. Retrieved 2015/02/19.
• 2、 Sorochinsky, Alexander E.,Ueki, Hisanori,Ace?a, José Luis,Ellis, Trevor K.,Moriwaki, Hiroki,Sato, Tatsunori,Soloshonok, Vadim A.. "Chemical approach for interconversion of (S)- and (R)-α-amino acids". . p. 4503 - 4507. Retrieved 2013/08/23.