2,3,4,5-tetramethylbenzoic acid

Base Information

• Chemical Name: 2,3,4,5-tetramethylbenzoic acid
• CAS No.: 2529-39-7
• Molecular Formula: C11H14 O2
• Molecular Weight: 178.231
• Hs Code.: 2916399090
• Mol file: 2529-39-7.mol

Synonyms:2,3,4,5-Tetramethylbenzoicacid

Chemical Property of 2,3,4,5-tetramethylbenzoic acid

Chemical Property:

• Vapor Pressure: 8.26E-05mmHg at 25°C
• Boiling Point: 327.3°Cat760mmHg
• Flash Point: 152.2°C
• PSA: 37.30000
• Density: 1.066g/cm³
• LogP: 2.61840

Purity/Quality:

99% ^*data from raw suppliers

2,3,4,5-TETRAMETHYL-BENZOIC ACID AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3,4,5-tetramethylbenzoic acid

There total 12 articles about 2,3,4,5-tetramethylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2',3',4',5'-tetramethylacetophenone (34764-71-1) → 2,3,4,5-tetramethylbenzoic acid (2529-39-7)

Guidance literature:

With bromine; potassium hydroxide; In 1,4-dioxane; water; at 0 - 20 ℃; for 2h; Reflux;

DOI:10.1021/jo201491q

Reference yield:

1,2,4,5-tetramethylbenzene (95-93-2) → 2,3,4,5-tetramethylbenzoic acid (2529-39-7)

Guidance literature:

Multi-step reaction with 2 steps

1: AlCl₃

2: H₂O / acetone / Heating

With aluminium trichloride; water; In acetone;

DOI:10.1021/ja01482a037

Reference yield:

2,3,4,5-tetramethylbenztrichloride (1079-50-1) → 2,3,4,5-tetramethylbenzoic acid (2529-39-7)

Guidance literature:

With water; In acetone; Heating;

DOI:10.1021/ja01482a037

upstream raw materials:

carbamic chloride

1,2,3,4-Tetramethylbenzene

pentamethylbenzene,

2',3',4',5'-tetramethylacetophenone

Downstream raw materials:

2.3.4.5-Tetramethylbenzoyl chloride

2-iodo-3,4,5,6-tetramethylbenzoic acid

3-sec-butyl-2,4,6-trimethylbenzoic acid

3,4,5,6-tetramethyl-1,2-dinitrobenzene

Refernces