TETRAHYDRO-THIOPHEN-3-OL

Base Information

• Chemical Name: TETRAHYDRO-THIOPHEN-3-OL
• CAS No.: 3334-05-2
• Molecular Formula: C4H8OS
• Molecular Weight: 104.173
• Hs Code.: 2934999090
• Mol file: 3334-05-2.mol

Synonyms:Thiophene-3-ol,tetrahydro-, (?à)-;3-Hydroxythiophane;NSC 241152;Tetrahydrothiophen-3-ol;Tetrahydrothiophene-3-ol;Thiacyclopentan-3-ol;

Chemical Property of TETRAHYDRO-THIOPHEN-3-OL

Chemical Property:

• Vapor Pressure: 0.0771mmHg at 25°C
• Refractive Index: 1.576
• Boiling Point: 201.2 °C at 760 mmHg
• Flash Point: 98.7 °C
• PSA: 45.53000
• Density: 1.222g/cm³
• LogP: 0.48420
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Tetrahydrothiophen-3-ol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TETRAHYDRO-THIOPHEN-3-OL

There total 6 articles about TETRAHYDRO-THIOPHEN-3-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

Tetrahydrothiophen-3-one (1003-04-9) → tetrahydrothiophene-3-ol (3334-05-2,79107-71-4)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 5 - 20 ℃;

DOI:10.1016/j.tetasy.2014.10.020

Reference yield: 93.5%

→ tetrahydrothiophene-3-ol (3334-05-2,79107-71-4)

Guidance literature:

Reference yield: 82.0%

glucose dehydrogenase + Tetrahydrothiophen-3-one (1003-04-9) + D-glucose (50-99-7) + NADP-Na2 → tetrahydrothiophene-3-ol (3334-05-2,79107-71-4)

Guidance literature:

With NaOH; Na₂S₂O₅; magnesium sulfate; In ethyl acetate;

upstream raw materials:

2,3-dihydrothiophene

Tetrahydrothiophen-3-one

1,4-dibromo-2-butanol

D-glucose

Refernces

• 1、 Konuki, Kaname,Nagai, Hazuki. "Enantiomeric purity enrichment of (R)-tetrahydrothiophene-3-ol sulfonyl derivatives by crystallization". . p. 1581 - 1589. Retrieved 2014.
• 2、 Machado, Naira Vieira,Omori, álvaro Takeo. "Enantioselective reduction of heterocyclic ketones with low level of asymmetry using carrots". . p. 475 - 480. Retrieved 2021/09/27.