Mylis

Base Information

• Chemical Name: Mylis
• CAS No.: 1099-87-2
• Molecular Formula: C19H27NaO5S
• Molecular Weight: 390.476
• European Community (EC) Number: 214-152-2
• Wikipedia: Prasterone_sodium_sulfate
• Mol file: 1099-87-2.mol

Synonyms:1099-87-2;Mylis;Androst-5-en-17-one, 3-(sulfooxy)-, sodium salt, (3b)-;C19H28O5S.Na;C19H27NaO5S.2H2O;C19-H27-O5-S.Na;SCHEMBL3920207

Chemical Property of Mylis

Chemical Property:

• Appearance/Colour: White to off-white powder
• Melting Point: 148-149 °C (dec.)(lit.)
• Refractive Index: 10 ° (C=4, MeOH)
• Flash Point: 9℃
• PSA: 91.88000
• LogP: 4.44450
• Storage Temp.: ?20°C
• Solubility.: methanol: clear to hazy
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 391.15551444
• Heavy Atom Count: 26
• Complexity: 721

Purity/Quality:

99.0% Min ^*data from raw suppliers

Dehydroepiandrosterone 3-sulfate (DHEAS) sodium salt solution 1.0?mg/mL in methanol (as free sulfate), ampule of 1?mL, certified reference material, Cerilliant? ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F, C
• Hazard Codes: F,C,T
• Statements: 11-34-39/23/24/25-23/24/25
• Safety Statements: 16-26-36/37/39-45-36/37-7

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC12CCC3C(C1CCC2=O)CC=C4C3(CCC(C4)OS(=O)(=O)O)C.[Na]
• Isomeric SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CCC2=O)CC=C4[C@@]3(CC[C@@H](C4)OS(=O)(=O)O)C.[Na]
• Description: Dehydroepiandrosterone sulfate (DHEAS) is a metabolite of dehydroepiandrosterone that is the major secretory product of adrenal glands and is the predominant circulating precursor for active steroid hormones in humans. For example, in the fetoplacental-maternal unit, DHEAS acts as the primary precursor for placental estrogen biosynthesis. A normal circulating concentration of DHEAS is ~10 μM in young adults and is dramatically increased in some adrenocortical disorders.
• Uses: An active agent in the preparation of a pharmaceutical for the treatment of asthma or other respiratory diseases.

Technology Process of Mylis

There total 2 articles about Mylis which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dehydroepiandrosterone (53-43-0) → Sodium prasterone sulfate (1099-87-2)

Guidance literature:

With pyridine; chlorosulfonic acid; at 22 ℃; for 2h;

DOI:10.1002/cbdv.201300286

Reference yield:

→ Sodium prasterone sulfate (1099-87-2)

Guidance literature:

With water; sodium chloride;

Reference yield:

hydrogenchloride (7647-01-0,15364-23-5) + Sodium prasterone sulfate (1099-87-2) → dehydroepiandrosterone (53-43-0)

Guidance literature:

at 25 ℃;

DOI:10.1021/ja01184a040

upstream raw materials:

dehydroepiandrosterone

Downstream raw materials:

dehydroepiandrosterone

Refernces