Ferrocene, (carboxymethyl)-

Base Information

• Chemical Name: Ferrocene, (carboxymethyl)-
• CAS No.: 1287-16-7
• Molecular Formula: C12H12 Fe O2
• Molecular Weight: 244.073
• Hs Code.: 29319090
• Mol file: 1287-16-7.mol

Synonyms:Ferrocene, (carboxymethyl)-;NSC608975;NSC 128978;FERROCENYL ACETIC ACID;MOUVOWJUMAKBBM-UHFFFAOYSA-N;AKOS028109502;J-005621;ferrous;cyclopenta-1,3-diene;2-cyclopenta-1,3-dien-1-ylacetic acid

Chemical Property of Ferrocene, (carboxymethyl)-

Chemical Property:

• Appearance/Colour: gold powder
• Melting Point: 158-160 °C(lit.)
• PSA: 37.30000
• LogP: 1.88540
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 244.018665
• Heavy Atom Count: 15
• Complexity: 115

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ferroceneacetic Acid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: [CH-]1C=CC=C1.[CH-]1C=CC=C1CC(=O)O.[Fe+2]
• Uses: Ferroceneacetic acid is a versatile catalyst. Also used in the preparation of silver nanoparticles as well as in the synthesis of redox-triggered drug delivery vesicles for cancer cell treatment.

Technology Process of Ferrocene, (carboxymethyl)-

There total 7 articles about Ferrocene, (carboxymethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

acetylferrocene (1271-55-2) → ferroceneacetic acid (1287-16-7)

Guidance literature:

acetylferrocene; With morpholine; sodiumsulfide nonahydrate; sulfur; at 128 ℃; for 7h;

With sodium hydroxide; In ethanol; water; for 4h; Temperature; Reflux;

Reference yield: 74.0%

2-ferrocenylacetonitrile + potassium hydroxide → ferroceneacetic acid (1287-16-7)

Guidance literature:

In ethanol; water; soln. of Fe complex in EtOH added to soln. of KOH; stirred at room temp.for 5 h; concd.; diluted in H2O; aq. layer extd. with Et2O; soln. of HCl added dropwise with stirring; filtered; ppt. washed with cold H2O;

DOI:10.1039/c0nj00902d

Reference yield:

C10H9FeCH2CS-morpholino → ferroceneacetic acid (1287-16-7)

Guidance literature:

With NaOH or KOH; In water; boiling H2O;

DOI:10.1021/ja01570a028 DOI:10.1021/ja01570a027 DOI:10.1039/JR9580000656

upstream raw materials:

water

acetylferrocene

Downstream raw materials:

ferrocenecarboxaldehyde

ferrocenecarboxylic acid

1-ferrocenylmethanol

carbon dioxide

Refernces

• 1、 Tatistcheff, Helen B.,Hancock, Lawrence F.,Wrighton, Mark S.. "Charge-Transfer-to-Solvent Photochemistry of Electrode-Confined Ferrocene- and Cobaltocene-Based Polymers: Photoelectrochemical Reduction of Halocarbons". . p. 7689 - 7693. Retrieved 1995.
• 2、 Chatelain, Gregory,Meyer, Albert,Morvan, Franois,Vasseur, Jean-Jacques,Chaix, Carole. "Electrochemical detection of nucleic acids using pentaferrocenyl phosphoramidate α-oligonucleotides". . p. 893 - 901. Retrieved 2011.
• 3、 -. "A process for preparing 3 - substituted - 6 - ferrocenyl methylene - 1, 2, 4 - triazolo [3.4 - b] - 1, 3, 4 - thiadiazole method". Paragraph 0033; 0042; 0051; 0060; 0069. . Retrieved 2017/11/21.