(4-Bromoanilino)azanium;chloride

Base Information

• Chemical Name: (4-Bromoanilino)azanium;chloride
• CAS No.: 41931-18-4
• Molecular Formula: C₆H₈BrN₂*Cl
• Molecular Weight: 223.5
• Mol file: 41931-18-4.mol

Synonyms:(4-bromoanilino)azanium;chloride

Chemical Property of (4-Bromoanilino)azanium;chloride

Chemical Property:

• Vapor Pressure: 0.00278mmHg at 25°C
• Melting Point: 220-230 °C (dec.)(lit.)
• Boiling Point: 285.6°C at 760 mmHg
• Flash Point: 126.5°C
• PSA: 38.05000
• LogP: 3.31000
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 221.95594
• Heavy Atom Count: 10
• Complexity: 79.1

Purity/Quality:

99% ^*data from raw suppliers

4-Bromophenylhydrazine hydrochloride 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R34:
• Hazard Codes: C,Xi
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=CC=C1N[NH3+])Br.[Cl-]

Technology Process of (4-Bromoanilino)azanium;chloride

There total 26 articles about (4-Bromoanilino)azanium;chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.3%

4-bromo-aniline (106-40-1) → 4-bromophenylhydrazine hydrochloride (622-88-8,41931-18-4)

Guidance literature:

4-bromo-aniline; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.5h; Inert atmosphere;

With tin(ll) chloride; In water; at 20 ℃; for 3h; Inert atmosphere;

Reference yield: 96.0%

4-bromo-aniline (106-40-1) → (4-bromophenyl)hydrazine hydrochloride salt (41931-18-4)

Guidance literature:

4-bromo-aniline; With nitrosylsulfuric acid; In water; at 30 ℃; Acidic conditions; Flow reactor;

With sodium dithionite; In water; at 80 - 120 ℃;

With hydrogenchloride; In water; at 130 ℃;

Reference yield: 72.0%

1.4-dibromobenzene (106-37-6) → 4-bromophenylhydrazine hydrochloride (622-88-8,41931-18-4)

Guidance literature:

1.4-dibromobenzene; With potassium phosphate; copper(l) iodide; N,N′-bis(2,6-dimethylphenyl)oxalamide; cetyltrimethylammonim bromide; In water; at 80 ℃; for 0.25h; Schlenk technique; Inert atmosphere; Sealed tube;

With hydrazine hydrate; In water; at 80 ℃; Inert atmosphere; Schlenk technique; Sealed tube;

With hydrogenchloride; In water; pH=3 - 4; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1002/cjoc.201800326

upstream raw materials:

phenylhydrazine

4-bromo-aniline

(4-bromophenyl)diazonium chloride

(3R,4S)-4-hydroxy-2-oxotetrahydrofuran-3-yl 2-(2-(4-bromophenyl)hydrazinyl)-2-oxoethanoate

Downstream raw materials:

N-[2-(5-bromo-1H-indol-3-yl)ethyl]benzamide

methyl 4-((6-bromo-2,2-dimethyl-4-oxo-1,2,3,4-tetrahydro carbazol-9-yl)methyl)benzoate

4-((6-bromo-2,2-dimethyl-4-oxo-1,2,3,4-tetrahydrocarbazol-9-yl)methyl)-N-hydroxybenzamide

methyl 1-(4-bromophenyl)-4-methyl-1,4-dihydropyrazolo-[4,3-c][1,2]benzothiazine-3-carboxylate 5,5-dioxide

Refernces

• 1、 Zhou, Yuan,Zhang, Shasha,Cai, Meng,Wang, Kaixing,Feng, Jiangtao,Xie, Dan,Feng, Lingling,Peng, Hao,He, Hongwu. "Design, Synthesis, and Antifungal Activity of 2,6-Dimethyl-4-aminopyrimidine Hydrazones as PDHc-E1 Inhibitors with a Novel Binding Mode". . p. 5804 - 5817. Retrieved 2021/06/25.
• 2、 -. "Heterocyclic com pounds and organic light-emitting diode including the same". Paragraph 0657-0663. . Retrieved 2021/01/19.