4-Hydroxy-6-aminopyrimidine

Base Information

• Chemical Name: 4-Hydroxy-6-aminopyrimidine
• CAS No.: 1193-22-2
• Molecular Formula: C4H5N3O
• Molecular Weight: 111.103
• Hs Code.: 2933599090
• Mol file: 1193-22-2.mol

Synonyms:4(1H)-Pyrimidinone,6-amino- (8CI,9CI);4-Pyrimidinol, 6-amino- (7CI);4-Amino-6-pyrimidinol;4-Hydroxy-6-aminopyrimidine;NSC 19868;

Chemical Property of 4-Hydroxy-6-aminopyrimidine

Chemical Property:

• Appearance/Colour: White to slight yellow crystalline powder
• Vapor Pressure: 0.0772mmHg at 25°C
• Melting Point: 262-264 °C
• Refractive Index: 1.688
• Boiling Point: 227.5 °C at 760 mmHg
• PKA: 10.04±0.40(Predicted)
• Flash Point: 91.4 °C
• PSA: 71.77000
• Density: 1.55 g/cm³
• LogP: -0.06670
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: DMSO

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Aminopyrimidin-4-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-41
• Safety Statements: 26-36-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Hydroxy-6-aminopyrimidine

There total 7 articles about 4-Hydroxy-6-aminopyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.4%

4-aminothiouracil (1004-40-6) → 6-amino-4-hydroxy-[3,4-d]pyrimidine (1193-22-2)

Guidance literature:

With ammonia; nickel; titanium(IV) oxide; In water; at 90 ℃; for 5h; Temperature; Reagent/catalyst;

Reference yield: 47.0%

6-amino-2-thioxo-1,2-dihydro-4(3H)-pyrimidinone (1004-40-6) → 6-Amino-3,4-dihydropyrimidin-4-one (1193-22-2)

Guidance literature:

With ammonium hydroxide; nickel; for 1h; Heating;

DOI:10.1002/(SICI)1521-3765(20000317)6:6<971::AID-CHEM971>3.0.CO;2-0

Reference yield:

6-amino-4-hydroxypyrimidine-2(1H)-thione (1004-40-6) → 6-amino-4-hydroxy-[3,4-d]pyrimidine (1193-22-2)

Guidance literature:

With ammonia; nickel; In water; for 2h; Heating / reflux;

upstream raw materials:

6-Amino-2-thiouracil

carbamoylacetamidine

formic acid ethyl ester

ammonia

Downstream raw materials:

6-amino-3-methylpyrimidin-4(3H)-one

4-amino-6-chloropyrimidine

6-amino-5-nitro-3H-pyrimidin-4-one

Allopurinol

Refernces

• 1、 -. "Preparation method of prodrug intermediate of thymidine phosphorylase inhibitor". Paragraph 0041; 0045-0046; 0049; 0053-0054; 0057; 0061-0062. . Retrieved 2021/04/14.
• 2、 -. "Synthesis process of 4-chloropyrrolo[2,3-D]pyrimidine". Paragraph 0023. . Retrieved 2016/12/01.