ETHYL PHENYLPHOSPHINATE

Base Information

• Chemical Name: ETHYL PHENYLPHOSPHINATE
• CAS No.: 2511-09-3
• Molecular Formula: C₈H₁₁O₂P
• Molecular Weight: 170.148
• European Community (EC) Number: 607-554-8
• NSC Number: 300841
• Mol file: 2511-09-3.mol

Synonyms:Phosphinicacid, phenyl-, ethyl ester (6CI,7CI,8CI,9CI);Ethoxyphenylphosphine oxide;Ethyl benzenephosphinite;Ethyl phenylphosphinate;NSC 300841;O-Ethylphenylphosphinate;Phenylphosphinic acid ethyl ester;

Chemical Property of ETHYL PHENYLPHOSPHINATE

Chemical Property:

• Vapor Pressure: 0.053mmHg at 25°C
• Refractive Index: n20/D 1.526(lit.)
• Boiling Point: °Cat760mmHg
• Flash Point: 113 ºC
• PSA: 49.77000
• Density: 1.129
• LogP: 1.82310
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 169.04184156
• Heavy Atom Count: 11
• Complexity: 130

Purity/Quality:

99% ^*data from raw suppliers

Ethyl Phenylphosphinate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCO[P+](=O)C1=CC=CC=C1
• Uses: Ethyl phenylphosphinate may be used in the preparation of the following diethyl imidazol-2-yl-(amino) methylphosphonates and phosphinates:imidazol-2-yl-methyl(N-butylamino)phosphonate diethyl esterimidazol-2-yl-methyl(N-benzylamino)phosphonate diethyl esterimidazol-2-yl-methyl(N-butylamino)phenylphosphinate ethyl esterimidazol-2-yl-methyl(N-benzylamino)phenylphosphinate ethyl ester

Technology Process of ETHYL PHENYLPHOSPHINATE

There total 35 articles about ETHYL PHENYLPHOSPHINATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethanol (64-17-5) + Dichlorophenylphosphine (644-97-3) → ethyl Phenylphosphinate (172487-18-2,2511-09-3)

Guidance literature:

In diethyl ether; at 20 ℃; for 0.5h;

DOI:10.1039/b309837k

Reference yield: 99.0%

phenylphosphinic acid (1779-48-2) + chloroformic acid ethyl ester (541-41-3) → ethyl Phenylphosphinate (172487-18-2,2511-09-3)

Guidance literature:

phenylphosphinic acid; chloroformic acid ethyl ester; With pyridine; In dichloromethane; at 20 ℃;

for 0.25h; Heating;

DOI:10.1016/S0040-4039(02)02647-3

Reference yield: 97.0%

phenylphosphinic acid (1779-48-2) + ethyl iodide (75-03-6) → ethyl Phenylphosphinate (172487-18-2,2511-09-3)

Guidance literature:

With triethylamine; In neat (no solvent); at 80 ℃; for 0.0833333h; Microwave irradiation;

DOI:10.1039/c4ra03292f

upstream raw materials:

diethyl phenylphosphonite

ethanol

Dichlorophenylphosphine

P,P-dichlorophenylphosphine oxide

Downstream raw materials:

phenyl-(2-[2]pyridyl-ethyl)-phosphinic acid ethyl ester

(2-acetoxy-ethyl)-phenyl-phosphinic acid ethyl ester

ethyl 2-cyanoethyl(phenyl)-phosphinate

Nonyl-phenyl-phosphinsaeure-ethylester

Refernces

• 1、 Xu, Ronghua,Gao, Zhenhua,Yu, Yiteng,Tang, Yehua,Tian, Duanshuai,Chen, Tian,Chen, Yibing,Xu, Guangqing,Shi, Enxue,Tang, Wenjun. "A facile and practical preparation ofP-chiral phosphine oxides". supporting information. p. 3335 - 3338. Retrieved 2021/04/07.
• 2、 Hou, Hong,Zhou, Bing,Wang, Jiawei,Sun, Duhao,Yu, Huaguang,Chen, Xiaoyun,Han, Ying,Shi, Yaocheng,Yan, Chaoguo,Zhu, Shaoqun. "Visible-light-induced ligand to metal charge transfer excitation enabled phosphorylation of aryl halides". supporting information. p. 5702 - 5705. Retrieved 2021/06/16.