1-Bromo-2-iodo-4-nitrobenzene

Base Information

• Chemical Name: 1-Bromo-2-iodo-4-nitrobenzene
• CAS No.: 63037-63-8
• Molecular Formula: C6H3BrINO2
• Molecular Weight: 327.904
• Hs Code.: 2904990090
• Mol file: 63037-63-8.mol

Synonyms:1-Brom-2-jod-4-nitro-benzol;4-nitro-1-bromo-2-iodobenzene;1-bromo-2-iodo-4-nitro-benzene;4-Bromo-3-iodonitrobenzene;

Chemical Property of 1-Bromo-2-iodo-4-nitrobenzene

Chemical Property:

• Vapor Pressure: 0.000316mmHg at 25°C
• Boiling Point: 330.6°Cat760mmHg
• Flash Point: 153.8°C
• PSA: 45.82000
• Density: 2.349g/cm³
• LogP: 3.48510
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

4-Bromo-3-iodonitrobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Bromo-2-iodo-4-nitrobenzene is used as a reactant in the iodination of deactivated aromatics with N-?iodosuccinimide.

Technology Process of 1-Bromo-2-iodo-4-nitrobenzene

There total 3 articles about 1-Bromo-2-iodo-4-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-bromo 5-nitroaniline (10403-47-1) → 1-bromo-2-iodo-4-nitrobenzene (63037-63-8)

Guidance literature:

2-bromo 5-nitroaniline; With tert.-butylnitrite; boron trifluoride diethyl etherate; In tetrahydrofuran; at -30 - 0 ℃; Inert atmosphere;

With iodine; potassium iodide; In acetonitrile; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1002/anie.201408424

Reference yield: 74.0%

para-nitrophenyl bromide (586-78-7) → 1-bromo-2-iodo-4-nitrobenzene (63037-63-8)

Guidance literature:

With N-iodo-succinimide; trifluorormethanesulfonic acid; for 2h; Ambient temperature;

DOI:10.1021/jo00063a052

Reference yield:

→ 1-bromo-2-iodo-4-nitrobenzene (63037-63-8)

Guidance literature:

With sulfuric acid; hydrogen bromide; acetic acid; copper(I) bromide;

upstream raw materials:

2-bromo 5-nitroaniline

para-nitrophenyl bromide

Downstream raw materials:

4-bromo-3-iodoaniline

1-ethyl-5-(4-bromo-3-iodo-phenyl)-biguanide

2-bromo-5-nitro-1,1'-biphenyl

Refernces

• 1、 Rickhaus, Michel,Bannwart, Linda Maria,Unke, Oliver,Gsellinger, Heiko,H?ussinger, Daniel,Mayor, Marcel. "Through the maze: Cross-coupling pathways to a helical hexaphenyl "Gel?nder" molecule". . p. 786 - 801. Retrieved 2015/01/30.
• 2、 Chaikovskii, V. K.,Kharlova, T. S.,Filimonov, V. D.. "Iodination of nitroarenes by a superactive reagent based on iodine chloride". . p. 1291 - 1294. Retrieved 2007/10/03.