Glucagon-like peptide-I(7-36) amide

Base Information

• Chemical Name: Glucagon-like peptide-I(7-36) amide
• CAS No.: 107444-51-9
• Deprecated CAS: 113789-12-1,873133-88-1
• Molecular Formula: C149H226N40O45
• Molecular Weight: 3297.67
• Mol file: 107444-51-9.mol

Synonyms:beinaglutide;GLP-1-(7-36);GLP-I (7-36);glucagon-like peptide 1 (7-36);glucagon-like peptide I (7-36);proglucagon (78-107)

Chemical Property of Glucagon-like peptide-I(7-36) amide

Chemical Property:

• Appearance/Colour: White powder
• PSA: 1385.09000
• Density: 1.47 g/cm³
• LogP: 2.02870
• Storage Temp.: −20°C
• Water Solubility.: Soluble in water (1 mg/ml).
• XLogP3: -14.2
• Hydrogen Bond Donor Count: 49
• Hydrogen Bond Acceptor Count: 50
• Rotatable Bond Count: 109
• Exact Mass: 3296.6659301
• Heavy Atom Count: 234
• Complexity: 7660

Purity/Quality:

99% ^*data from raw suppliers

Glucagon-Like Peptide-1 (7-36) amide, human ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(C)C(C(=O)NC(C)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NCC(=O)NC(CCCNC(=N)N)C(=O)N)NC(=O)C(CC3=CC=CC=C3)NC(=O)C(CCC(=O)O)NC(=O)C(CCCCN)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CCC(=O)N)NC(=O)CNC(=O)C(CCC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(C(C)C)NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(CC5=CC=CC=C5)NC(=O)C(C(C)O)NC(=O)CNC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(CC6=CNC=N6)N
• Isomeric SMILES: CC[C@H](C)[C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)N)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC5=CC=CC=C5)NC(=O)[C@H]([C@@H](C)O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CC6=CNC=N6)N
• Recent ClinicalTrials: Effect of GLP - 1 (7-36 Amide) on Myocardial Function Following Coronary Artery Bypass (CABG) Surgery
• Recent EU Clinical Trials: A phase II study to investigate the protective effects of Glucagon--like Peptide--1 (GLP--1) in patients undergoing elective angioplasty and stenting.
• Uses: Diabetes?II?-?not?yet?an?approved?application Glucagon-Like Peptide-1 is used as a Effector in the hormonal control of insulin secretion. The peptide fragment is secreted from the lower small intestine. Its action is mediated by receptors expressed by the endocrine pancreatic B-cells. Glucagon-Like Peptide (GLP) I Amide Fragment 7-36 human has been used as a GLP-1 receptor agonist: in lysate transfer cyclic adenosine monophosphate (cAMP) assay to test its effect on adenylyl cyclase activityto pre-treat the human umbilical vein endothelial cells (HUVECs) to monitor its effect on hyperpermeability in endothelial cell (EC) monolayers and changes with the actin cytoskeletonto test its inhibitory effect on vascular endothelial growth factor-A (VEGFA) based vasodilation in rat mesenteric arteries