Cophylline

Base Information

• Chemical Name: Cophylline
• CAS No.: 142741-24-0
• Molecular Formula: C₄₄H₅₀N₄O₁₀
• Molecular Weight: 794.902
• Mol file: 142741-24-0.mol

Synonyms:[8,15'-Biaspidospermidine]-3,3'-dicarboxylicacid,2,2',3,3'-tetradehydro-6',7':7,16'-diepoxy-6,15-dihydroxy-16,17-dimethoxy-,dimethyl ester, (5a,6b,7a,8a,12b,19a)-(5'a,6'b,7'b,12'b,19'a)-;2H,22H-Indolo[2'',3'':7',8']pyrrolo[1'',2'',3'':1',8']quino[2',3':4,5]furo[2,3-b]oxireno[6,7]indolizino[1,8-fg]carbazole,[8,15'-biaspidospermidine]-3,3'-dicarboxylic acid deriv.; Aspidospermidine,bimol. deriv.; Conophylline; Polyervine; Vinca alkaloid III-121C

Chemical Property of Cophylline

Chemical Property:

• PSA: 163.82000
• LogP: 4.14860

Purity/Quality:

98%min ^*data from raw suppliers

Conophylline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Conophylline can be used in pharmacological activity and therapeutic use of differentiation of adipose-derived stem cells into functional islet-like cells using conophlline and nicotinamide.

Technology Process of Cophylline

There total 2 articles about Cophylline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

conophylline quinone → conophylline (142741-24-0)

Guidance literature:

With sodium tetrahydroborate; In dichloromethane;

DOI:10.1039/b301167d

Reference yield: 72.0%

C48H53Cl3N4O14S (1310878-82-0) → conophylline (142741-24-0)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -78 - 0 ℃; Inert atmosphere;

DOI:10.1002/anie.201100981

upstream raw materials:

C₄₈H₅₃Cl₃N₄O₁₄S

Refernces

• 1、 Han-Ya, Yuki,Tokuyama, Hidetoshi,Fukuyama, Tohru. "Total synthesis of (-)-conophylline and (-)-conophyllidine". supporting information; experimental part. p. 4884 - 4887. Retrieved 2011/06/26.