3',5-Dihydroxy-4',5',6,7-tetramethoxyflavone

Base Information

• Chemical Name: 3',5-Dihydroxy-4',5',6,7-tetramethoxyflavone
• CAS No.: 111537-41-8
• Molecular Formula: C₁₉H₁₈O₈
• Molecular Weight: 374.347
• Hs Code.: 2932999099
• Mol file: 111537-41-8.mol

Synonyms:5,3'-Dihydroxy-6,7,4',5'-tetramethoxyflavone

Chemical Property of 3',5-Dihydroxy-4',5',6,7-tetramethoxyflavone

Chemical Property:

• Vapor Pressure: 1.1E-15mmHg at 25°C
• Boiling Point: 614.3°Cat760mmHg
• Flash Point: 222.1°C
• PSA: 107.59000
• Density: 1.375g/cm³
• LogP: 2.90560

Purity/Quality:

98%min ^*data from raw suppliers

3',5-Dihydroxy-4',5',6,7-tetramethoxyflavone ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3',5-Dihydroxy-4',5',6,7-tetramethoxyflavone

There total 7 articles about 3',5-Dihydroxy-4',5',6,7-tetramethoxyflavone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-hydroxy-2,3,4-trimethoxyacetophenone (22248-14-2) → 5,3‘-dihydroxy-6,7,4‘,5‘-tetramethoxyflavone (111537-41-8)

Guidance literature:

Multi-step reaction with 5 steps

1: KOH / aq. ethanol

2: 85percent H₃PO₄ / ethanol / Heating

3: DDQ / dioxane / Heating

4: H₂ / Pd-C / ethyl acetate

5: BCl₃ / CH₂Cl₂

With potassium hydroxide; phosphoric acid; hydrogen; boron trichloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium on activated charcoal; In 1,4-dioxane; ethanol; dichloromethane; ethyl acetate;

Reference yield:

3,4-dimethoxy-5-benzyloxybenzaldehyde (57230-04-3) → 5,3‘-dihydroxy-6,7,4‘,5‘-tetramethoxyflavone (111537-41-8)

Guidance literature:

Multi-step reaction with 5 steps

1: KOH / aq. ethanol

2: 85percent H₃PO₄ / ethanol / Heating

3: DDQ / dioxane / Heating

4: H₂ / Pd-C / ethyl acetate

5: BCl₃ / CH₂Cl₂

With potassium hydroxide; phosphoric acid; hydrogen; boron trichloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium on activated charcoal; In 1,4-dioxane; ethanol; dichloromethane; ethyl acetate;

Reference yield:

3'-benzyloxy-4',5,5',6,7-pentamethoxyflavone (93092-23-0) → 5,3‘-dihydroxy-6,7,4‘,5‘-tetramethoxyflavone (111537-41-8)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd-C / ethyl acetate

2: BCl₃ / CH₂Cl₂

With hydrogen; boron trichloride; palladium on activated charcoal; In dichloromethane; ethyl acetate;

upstream raw materials:

6-hydroxy-2,3,4-trimethoxyacetophenone

3,4-dimethoxy-5-benzyloxybenzaldehyde

3'-benzyloxy-4',5,5',6,7-pentamethoxyflavone

Downstream raw materials:

3',4',5,5',6,7-Hexamethoxyflavone

Refernces

• 1、 Iinuma, Munekazu,Tanaka, Toshiyuki,Matsuura, Shin. "Synthetic Studies on the Flavone Derivatives. XII. Synthesis of 2',3',5'- and 3',4',5'-Trioxygenated Flavones". . p. 2296 - 2300. Retrieved 2007/10/02.