Tris(4-fluorophenyl)phosphine

Base Information

• Chemical Name: Tris(4-fluorophenyl)phosphine
• CAS No.: 18437-78-0
• Molecular Formula: C18H12F3P
• Molecular Weight: 316.262
• Hs Code.: 29319090
• European Community (EC) Number: 627-663-4
• NSC Number: 158458
• DSSTox Substance ID: DTXSID80171565
• Nikkaji Number: J126.187H
• Wikidata: Q72515152
• Mol file: 18437-78-0.mol

Synonyms:Tris(4-fluorophenyl)phosphine;18437-78-0;tris(4-fluorophenyl)phosphane;Phosphine, tris(4-fluorophenyl)-;Tris(p-fluorophenyl)phosphine;Phosphine, tris(p-fluorophenyl)-;MFCD00013553;TRI(4-FLUOROPHENYL)PHOSPHINE;C18H12F3P;NSC158458;p(4-fc6h4)3;SCHEMBL196718;tri-(4-Fluorophenyl)phosphine;tris (p-fluorophenyl)phosphine;DTXSID80171565;tris-(4-fluoro-phenyl)-phosphane;BCP21966;Tris(4-fluorophenyl)phosphine, 98%;AKOS004909006;CS-W009423;HY-W008707;NSC 158458;NSC-158458;SC11107;AS-59713;SY048540;FT-0637697;T2900;F17176;EN300-6746815;A812866;J-011818;PHOSPHINE, TRIS(4-FLUOROPHENYL)-;TRI-(P-FLUOROPHENYL)PHOSPHINE;TRIS(4-FLUOROPHENYL)PHOSPHINE;TRIS(4-FLUOROPHENYL)PHOSPHINE OXIDE;TRIS(P-FLUOROPHENYL)PHOSPHINE

Chemical Property of Tris(4-fluorophenyl)phosphine

Chemical Property:

• Appearance/Colour: white to very slightly yellow crystalline powder
• Vapor Pressure: 0.00301mmHg at 25°C
• Melting Point: 79-83 °C(lit.)
• Refractive Index: 1.558
• Boiling Point: 351.472 °C at 760 mmHg
• Flash Point: 166.365 °C
• PSA: 13.59000
• Density: 1.132g/cm³
• LogP: 3.86210
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive.: Air Sensitive
• Water Solubility.: Insoluble in water.
• XLogP3: 4.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 316.06287187
• Heavy Atom Count: 22
• Complexity: 275

Purity/Quality:

98%, ^*data from raw suppliers

tris(4-Fluorophenyl)phosphine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC(=CC=C1F)P(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F
• Uses: Tris(4-fluorophenyl)phosphine (TFPP) and tris(2,2,2- trifluoroethyl) phosphite (TTFP) were used as flame-retarding additives in Li-ion battery clectrolytes. Ligand for rhodium-catalyzed oxygenative addition to terminal alkynes for a greener synthesis esters, amides, and carboxylic acids. Tris(4-fluorophenyl)phosphine, is an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff. Ligand for rhodium-catalyzed oxygenative addition to terminal alkynes for a greener synthesis esters, amides, and carboxylic acids.Rhodium-Catalyzed Oxygenative Addition to Terminal Alkynes for the Synthesis of Esters, Amides, and Carboxylic Acids

Technology Process of Tris(4-fluorophenyl)phosphine

There total 7 articles about Tris(4-fluorophenyl)phosphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

tri(4-fluorophenyl)phosphine oxide (18437-79-1) → P(p-C6H4F)3 (18437-78-0)

Guidance literature:

With triphenyl phosphite; diphenyl hydrogen phosphite; iodine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1002/anie.201709519

Reference yield: 39.0%

→ P(p-C6H4F)3 (18437-78-0)

Guidance literature:

Reference yield:

1-Bromo-4-fluorobenzene (460-00-4) → P(p-C6H4F)3 (18437-78-0)

Guidance literature:

With magnesium; phosphorus trichloride; In tetrahydrofuran; for 1h; Heating;

DOI:10.1139/v82-106

upstream raw materials:

1-Bromo-4-fluorobenzene

(2-quinaldinate)(carbonyl)(P(4-F-C₅H₄)3)2rhodium(I)

(2-quinaldinate)(carbonyl)(P(4-F-C₅H₄)3)2rhodium(I)

tri(4-fluorophenyl)phosphine oxide

Downstream raw materials:

C₂₂H₁₂F₃O₃P

{platinum(II)(η3-allyl)(P(4-FC6H4)3)2}BF4

{(CO)4Cr{P(C₆H₄F-p)3}Cl}^(1-)

Mo(CO)3(C₅H₄NC₅H₄N)(P(C₆H₄F)3)

Refernces

• 1、 Taylor, Nicholas P.,Gonzalez, Jorge A.,Nichol, Gary S.,García-Domínguez, Andrés,Leach, Andrew G.,Lloyd-Jones, Guy C.. "A Lewis Base Nucleofugality Parameter, NFB, and Its Application in an Analysis of MIDA-Boronate Hydrolysis Kinetics". supporting information. p. 721 - 729. Retrieved 2022/01/04.
• 2、 -. "Synthesis method of phosphine (III) compound". Paragraph 0020. . Retrieved 2021/11/27.