2-Methyl-N-(oxetan-3-ylid...

Base Information

• Chemical Name: 2-Methyl-N-(oxetan-3-ylid...
• CAS No.: 1158098-73-7
• Molecular Formula: C7H13NO3S
• Molecular Weight: 175.252
• Hs Code.: 2932999099
• Mol file: 1158098-73-7.mol

Synonyms:2-Methyl-N-(oxetan-3-ylid...;2-Methyl-N-(oxetan-3-ylidene)propane-2-sulfinamide;2-Methyl-N-(3-oxetanylidene)-2-propanesulfinaMide;3-[(tert-Butylsulfinyl)imino]oxetan;2-Methyl-N-(oxetan-3-ylidene)propane-2-sulfinaMide 2-Methylpropane-2-sulfinic acid oxetan-3-ylideneaMide;2-Methyl-N-(3-oxetanylidene)propane-2-sulfinaMide, 95%

Chemical Property of 2-Methyl-N-(oxetan-3-ylid...

Chemical Property:

• Boiling Point: 302.8±52.0 °C(Predicted)
• PKA: -0.50±0.20(Predicted)
• PSA: 57.87000
• Density: 1.25
• LogP: 1.78550
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Water Solubility.: Soluble in water. (1.00E+06 mg/L).

Purity/Quality:

99% ^*data from raw suppliers

2-Methyl-N-(oxetan-3-ylidene)propane-2-sulfinamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,C
• Hazard Codes: F,C
• Statements: 36/37/38
• Safety Statements: 26-37-60

MSDS Files:

SDS file from LookChem

Useful:

• Uses: It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.

Technology Process of 2-Methyl-N-(oxetan-3-ylid...

There total 3 articles about 2-Methyl-N-(oxetan-3-ylid... which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

oxetan-3-one (6704-31-0) + S-tert-butylsulfinimide (146374-27-8) → (±)-2-methyl-N-(oxetan-3-ylidene)propane-2-sulfinamide (1158098-73-7)

Guidance literature:

With titanium(IV) isopropylate; In dichloromethane; at 20 ℃; Inert atmosphere; Reflux;

DOI:10.1021/ol201438k

Reference yield: 30.0%

3,3-dimethoxyoxetane (922500-97-8) + S-tert-butylsulfinimide (146374-27-8) → (±)-2-methyl-N-(oxetan-3-ylidene)propane-2-sulfinamide (1158098-73-7)

Guidance literature:

3,3-dimethoxyoxetane; In dichloromethane; at 48 ℃; for 72h; Inert atmosphere;

S-tert-butylsulfinimide; With titanium(IV) tetraethanolate; In tetrahydrofuran; at 50 ℃; for 5h; Inert atmosphere;

DOI:10.1021/ol100119e

Reference yield: 24.0%

oxetan-3-one (6704-31-0) + 2-methylpropane-2-sulfenamide (130439-58-6) → (±)-2-methyl-N-(oxetan-3-ylidene)propane-2-sulfinamide (1158098-73-7)

Guidance literature:

With titanium(IV) isopropylate; In dichloromethane; at 20 ℃; for 12h;

upstream raw materials:

oxetan-3-one

S-tert-butylsulfinimide

3,3-dimethoxyoxetane

2-methylpropane-2-sulfenamide

Downstream raw materials:

2-methyl-propane-2-sulfinic acid [3-(4-cyano-phenyl)-oxetan-3-yl]-amide

C₁₃H₁₈FNO₂S

C₁₃H₁₈ClNO₂S

2-methyl-N-(3-phenyloxetan-3-yl)propane-2-sulfinamide

Refernces

• 1、 Casimiro-Garcia, Agustin,Allais, Christophe,Brennan, Agnes,Choi, Chulho,Dower, Gabriela,Farley, Kathleen A.,Fleming, Margaret,Flick, Andrew,Frisbie, Richard K.,Hall, Justin,Hepworth, David,Jones, Hannah,Knafels, John D.,Kortum, Steve,Lovering, Frank E.,Mathias, John P.,Mohan, Sashi,Morgan, Paul M.,Parng, Chuenlei,Parris, Kevin,Pullen, Nick,Schlerman, Franklin,Stansfield, John,Strohbach, Joseph W.,Vajdos, Felix F.,Vincent, Fabien,Wang, Hong,Wang, Xiaolun,Webster, Robert,Wright, Stephen W.. "Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1". . p. 757 - 784. Retrieved 2022/01/20.
• 2、 -. "SPIROUREA DERIVATIVES". Page/Page column 88. . Retrieved 2021/11/06.