9-Methoxy-alpha-lapachone

Base Information

• Chemical Name: 9-Methoxy-alpha-lapachone
• CAS No.: 35241-80-6
• Molecular Formula: C16H16O4
• Molecular Weight: 272.2958
• Hs Code.: 2914509090
• Mol file: 35241-80-6.mol

Synonyms:9-Methoxy-α-lapachone;9-Methoxy-α-lapachone;9-Methoxy-alpha-lapachone;9-methoxy-2,2-dimethyl-3,4-dihydrobenzo[g]chromene-5,10-dione

Chemical Property of 9-Methoxy-alpha-lapachone

Chemical Property:

• Vapor Pressure: 8.93E-08mmHg at 25°C
• Refractive Index: 1.584
• Boiling Point: 435.2 °C at 760 mmHg
• Flash Point: 194.3 °C
• PSA: 52.60000
• Density: 1.26g/cm³
• LogP: 2.91730

Purity/Quality:

98%min ^*data from raw suppliers

9-Methoxy-alpha-lapachone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-Methoxy-alpha-lapachone

There total 8 articles about 9-Methoxy-alpha-lapachone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

9-methoxy-2,2-dimethyl-2H-naphtho<2,3-b>pyran-5,10-dione (58785-62-9) → 9-methoxy-α-lapachone (35241-80-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 1h; Ambient temperature;

Reference yield:

9-hydroxy-2,2-dimethyl-2H-benzo[g]chromene-5,10-dione (22333-57-9) → 9-methoxy-α-lapachone (35241-80-6)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd/C

2: K₂CO₃ / acetone

With hydrogen; potassium carbonate; palladium on activated charcoal; In acetone;

DOI:10.1016/S0040-4039(00)71140-3

Reference yield:

1-methoxy-1,3-cyclohexadiene (2161-90-2) → 9-methoxy-α-lapachone (35241-80-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 83 percent / methanol / 1 h / Ambient temperature

2: 1.) NaH, 2.) Ag₂O, MgSO₄ / 1.) THF, 0 deg C, 30 min, 2.) THF, 1.5 h

3: 83 percent / p-toluenesulfonic acid / xylene / 1.25 h / Heating

4: 99 percent / H₂ / 10percent Pd/C / ethanol / 1 h / Ambient temperature

With hydrogen; sodium hydride; magnesium sulfate; toluene-4-sulfonic acid; silver(l) oxide; palladium on activated charcoal; In methanol; ethanol; xylene;

upstream raw materials:

9-hydroxy-α-lapachone

dimethyl sulfate

9-methoxy-2,2-dimethyl-2H-naphtho<2,3-b>pyran-5,10-dione

1-methoxy-1,3-cyclohexadiene

Refernces

• 1、 Kapoor, N. K.,Gupta, R. B.,Khanna, R. N.. "SYNTHESIS OF SOME NATURALLY OCCURING PRENYLATED JUGLONE DERIVATIVES". . p. 5083 - 5084. Retrieved 2007/10/02.