1-(2-Bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea

Base Information Edit

Chemical Name:1-(2-Bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea
CAS No.:182498-32-4
Molecular Formula:C13H10BrN3O4
Molecular Weight:352.1402
Hs Code.:2921490090
European Community (EC) Number:803-197-9
DSSTox Substance ID:DTXSID20397383
Nikkaji Number:J951.652B
Wikidata:Q27088712
Pharos Ligand ID:J436KQYC9667
ChEMBL ID:CHEMBL239767
Mol file:182498-32-4.mol

Synonyms:N-(2-hydroxy-4-nitrophenyl)-N'-(2-bromophenyl)urea;SB 225002;SB-225002;SB225002

Suppliers and Price of 1-(2-Bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
SB 225002
10mg
$ 375.00

TRC
SB 225002
100mg
$ 125.00

Tocris
SB 225002 ≥99%(HPLC)
10
$ 218.00

Tocris
SB 225002 ≥99%(HPLC)
50
$ 917.00

TCI Chemical
SB 225002
50MG
$ 644.00

TCI Chemical
SB 225002
10MG
$ 195.00

Sigma-Aldrich
SB 225002 ≥98% (HPLC)
5mg
$ 100.00

Sigma-Aldrich
SB 225002
1mg
$ 85.65

Sigma-Aldrich
SB 225002 ≥98% (HPLC)
25mg
$ 404.00

DC Chemicals
SB 225002 >98%
1 g
$ 1350.00

Total 22 raw suppliers

Chemical Property of 1-(2-Bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea Edit

Chemical Property:

Vapor Pressure:5.05E-07mmHg at 25°C
Boiling Point:401.6°Cat760mmHg
Flash Point:196.7°C
PSA：107.18000
Density:1.793g/cm³
LogP:4.37610
Storage Temp.:-20°C
Sensitive.:Moisture Sensitive
Solubility.:Soluble to 100mM in DMSO and to 50mM in ethanol
XLogP3:2.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:350.98547
Heavy Atom Count:21
Complexity:390

Purity/Quality:

98%,99%, ^*data from raw suppliers

SB 225002 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C(=C1)NC(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])O)Br
Description CXCR2 (IL-8RB) is a seven-transmembrane G protein-coupled receptor whose physiological ligands include IL-8 (CXCL8) and growth related oncogene α (Gro-α; CXCL1). IL-8 and Gro-α are pro-inflammatory CXC chemokines that act as chemoattractants, especially for neutrophils, and promote angiogenesis. SB 225002 is a selective non-peptide inhibitor of CXCR2, inhibiting IL-8 binding to CXCR2 with an IC50 value of 22 nM. SB225002 inhibits neutrophil chemotaxis in response to IL-8 in vitro (IC50 = 20 nM) and blocks neutrophil margination induced by IL-8 in vivo (IC50 = 30 nM). Similarly, SB 225002 reduces neutrophil influx, the production of inflammatory mediators, and tissue damage in TNBS-induced colitis in mice.
Uses SB 225002 is a potent and selective CXCR2 antagonist with the ability to inhibit interleukin IL-8 binding to CXCR2.

Technology Process of 1-(2-Bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea

There total 2 articles about 1-(2-Bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%