2-Methoxycyclohexan-1-ol

Base Information

• Chemical Name: 2-Methoxycyclohexan-1-ol
• CAS No.: 2979-24-0
• Deprecated CAS: 1259093-39-4
• Molecular Formula: C7H14 O2
• Molecular Weight: 130.187
• Hs Code.: 2909499000
• European Community (EC) Number: 221-031-8
• DSSTox Substance ID: DTXSID90883546
• Nikkaji Number: J191.538J
• Mol file: 2979-24-0.mol

Synonyms:2-Methoxycyclohexan-1-ol;2-methoxycyclohexanol;2979-24-0;Cyclohexanol, 2-methoxy-;Cyclohexanol, 2-methoxy-, cis-;Cyclohexanol, 2-methoxy-, trans-;EINECS 221-031-8;AI3-21004;7429-41-6;7429-40-5;(RS)-2-methoxycyclohexanol;Cyclohexanol,2-methoxy-,cis-;SCHEMBL618206;Cyclohexanol,2-methoxy-,trans-;DTXSID90883546;MFCD00015373;AKOS009158392;SB45144;FT-0604565;FT-0628311;FT-0694019;EN300-42076;F73845;J-017643;Z425453594

Chemical Property of 2-Methoxycyclohexan-1-ol

Chemical Property:

• Vapor Pressure: 0.0931mmHg at 25°C
• Melting Point: 78-79 °C(Solv: acetone (67-64-1))
• Refractive Index: n20/D 1.46(lit.)
• Boiling Point: 198°Cat760mmHg
• PKA: 14.67±0.40(Predicted)
• Flash Point: 75.7°C
• PSA: 29.46000
• Density: 0.99g/cm³
• LogP: 0.93630
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 130.099379685
• Heavy Atom Count: 9
• Complexity: 83

Purity/Quality:

99% ^*data from raw suppliers

2-METHOXYCYCLOHEXAN-1-OL 95.00% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1CCCCC1O

Technology Process of 2-Methoxycyclohexan-1-ol

There total 122 articles about 2-Methoxycyclohexan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

2-methoxy-phenol (90-05-1) → cyclohexane (110-82-7,25012-93-5) + 1-amino-cyclopentanemethanol (3637-61-4) + 2-methoxycyclohexanol (2979-24-0)

Guidance literature:

With hydrogen; In isopropyl alcohol; at 250 ℃; under 22502.3 Torr; Autoclave;

DOI:10.1134/S0965544121090115

Reference yield: 17.0%

2-methoxy-phenol (90-05-1) → methanol (67-56-1) + p-cresol (106-44-5) + 2-methoxycyclohexane (931-56-6) + cyclohexane (110-82-7,25012-93-5) + 1,2-Cyclohexanediol (931-17-9) + 2-methoxycyclohexanol (2979-24-0) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + 3-methyl-phenol (108-39-4) + ortho-cresol (95-48-7,77504-84-8) + cyclohexanol (108-93-0) + phenol (108-95-2,27073-41-2)

Guidance literature:

With hydrogen; ruthenium; at 150 - 300 ℃; for 4h; Product distribution / selectivity;

Reference yield:

2-(2-methoxyphenoxy)-acetophenone (14385-48-9) → 1-Phenylethanol (98-85-1,13323-81-4) + 2-methoxycyclohexanol (2979-24-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 4 h / 25 °C

2: hydrogen / ethanol / 12 h / 80 °C / 760.05 Torr

With sodium tetrahydroborate; hydrogen; In methanol; ethanol;

DOI:10.1039/c6gc02265k

upstream raw materials:

2-methoxy-phenol

1,2-Cyclohexanediol

methyl iodide

methanol

Downstream raw materials:

Dimethyl-<2-methoxy-cyclohexyloxy>-chlor-silan

methanol

cyclohexanone

cyclohexane

Refernces

• 1、 Hu, Bin,Lu, Jinzhi,Ma, Zhanwei,Wei, Xuemei,Zhang, Qinsheng. "Support morphology-dependent catalytic activity of the Co/CeO2catalyst for the aqueous-phase hydrogenation of phenol". . p. 9298 - 9303. Retrieved 2020.
• 2、 Gu, Lin,Han, Jianyu,Liu, Haitao,Shi, Yanan,Tang, Zhiyong,Yang, Zhongjie,Zhang, Xiaofei. "Metalation of Catechol-Functionalized Defective Covalent Organic Frameworks for Lewis Acid Catalysis". . . Retrieved 2020.
• 3、 Chen, Henan,Kumar, Mohan,Liang, Baiyao,Peng, Tao,Wang, Miao,Yang, Chenxin,Zhang, Yun,Zhao, Wei. "Electrocatalytic hydrogenation of lignin monomer to methoxy-cyclohexanes with high faradaic efficiency". supporting information. p. 142 - 146. Retrieved 2022/01/19.
• 4、 Kalinina,Kulikov,Cherednichenko,Maximov,Karakhanov. "The Effect of Sulfonate Groups in the Structure of Porous Aromatic Frameworks on the Activity of Platinum Catalysts Towards Hydrodeoxygenation of Biofuel Components". . p. 1061 - 1070. Retrieved 2021/09/06.