1-(3-NITROPHENYLSULFONYL)PYRROLIDINE

Base Information

• Chemical Name: 1-(3-NITROPHENYLSULFONYL)PYRROLIDINE
• CAS No.: 91619-30-6
• Molecular Formula: C10H12 N2 O4 S
• Molecular Weight: 256.28
• Hs Code.: 2935009090
• Mol file: 91619-30-6.mol

Synonyms:NSC 61569

Chemical Property of 1-(3-NITROPHENYLSULFONYL)PYRROLIDINE

Chemical Property:

• Vapor Pressure: 3.52E-07mmHg at 25°C
• Boiling Point: 417.5°Cat760mmHg
• Flash Point: 206.3°C
• PSA: 91.58000
• Density: 1.432g/cm³
• LogP: 2.92120
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

1-((3-Nitrophenyl)sulfonyl)pyrrolidine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 1-(3-NITROPHENYLSULFONYL)PYRROLIDINE

There total 2 articles about 1-(3-NITROPHENYLSULFONYL)PYRROLIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

pyrrolidine (123-75-1) + 3-nitrobenzenesulphonyl chloride (121-51-7) → 1-(3-nitrophenylsulfonyl)pyrrolidine (91619-30-6)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 3h;

DOI:10.1021/acscombsci.5b00155

Reference yield: 82.0%

→ 1-(3-nitrophenylsulfonyl)pyrrolidine (91619-30-6)

Guidance literature:

With pyridine; dmap; In dichloromethane; at 0 ℃; for 0.25h;

In dichloromethane; at 20 ℃; for 5h;

Reference yield: 93.0%

1-(3-nitrophenylsulfonyl)pyrrolidine (91619-30-6) → 3-(pyrrolidin-1-ylsulfonyl)benzenamine (91619-38-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; for 18h;

DOI:10.1021/acscombsci.5b00155

upstream raw materials:

pyrrolidine

3-nitrobenzenesulphonyl chloride

Downstream raw materials:

3-(pyrrolidin-1-ylsulfonyl)benzenamine

Refernces

• 1、 Myers, Stephanie M.,Bawn, Ruth H.,Bisset, Louise C.,Blackburn, Timothy J.,Cottyn, Betty,Molyneux, Lauren,Wong, Ai-Ching,Cano, Celine,Clegg, William,Harrington, Ross. W.,Leung, Hing,Rigoreau, Laurent,Vidot, Sandrine,Golding, Bernard T.,Griffin, Roger J.,Hammonds, Tim,Newell, David R.,Hardcastle, Ian R.. "High-Throughput Screening and Hit Validation of Extracellular-Related Kinase 5 (ERK5) Inhibitors". supporting information. p. 444 - 455. Retrieved 2016/08/16.