(5-BROMO-2-FLUORO-PHENYL)-HYDRAZINE

Base Information

• Chemical Name: (5-BROMO-2-FLUORO-PHENYL)-HYDRAZINE
• CAS No.: 627871-08-3
• Molecular Formula: C6H6BrFN2
• Molecular Weight: 205.029
• Hs Code.: 2928000090
• Mol file: 627871-08-3.mol

Synonyms:(5-BROMO-2-FLUOROPHENYL)HYDRAZINE;(5-BROMO-2-FLUORO-PHENYL)-HYDRAZINE;5-BROMO-2-FLUORO-BENZAMIDINE;

Chemical Property of (5-BROMO-2-FLUORO-PHENYL)-HYDRAZINE

Chemical Property:

• Boiling Point: 247.0±30.0 °C(Predicted)
• PKA: 4.45±0.10(Predicted)
• PSA: 38.05000
• Density: 1.760±0.06 g/cm3(Predicted)
• LogP: 2.64710

Purity/Quality:

≥95% ^*data from raw suppliers

5-bromo-2-fluoro-benzamidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (5-BROMO-2-FLUORO-PHENYL)-HYDRAZINE

There total 2 articles about (5-BROMO-2-FLUORO-PHENYL)-HYDRAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

sodium nitrate (7631-99-4) + 5-bromo-2-fluoroaniline (2924-09-6) → (5-bromo-2-fluorophenyl)hydrazine (627871-08-3)

Guidance literature:

sodium nitrate; 5-bromo-2-fluoroaniline; With hydrogenchloride; In water; at 0 ℃; for 0.5h;

With hydrogenchloride; tin(ll) chloride; In water; at 0 ℃; for 1.5h;

With sodium hydroxide; In water;

Reference yield: 54.0%

5-bromo-2-fluoroaniline (2924-09-6) → (5-bromo-2-fluorophenyl)hydrazine (627871-08-3)

Guidance literature:

5-bromo-2-fluoroaniline; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.5h;

With hydrogenchloride; tin dichloride dihydrate; In water; at 0 ℃; for 1h;

Reference yield: 68.0%

oxo-(2-oxo-cyclopentyl)-acetic acid ethyl ester (39163-39-8) + (5-bromo-2-fluorophenyl)hydrazine (627871-08-3) → ethyl 1-(5-bromo-2-fluorophenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylate

Guidance literature:

With sulfuric acid; hydrazine hydrate; In ethanol; at 90 ℃; for 1h;

upstream raw materials:

sodium nitrate

5-bromo-2-fluoroaniline

Refernces

• 1、 -. "METHOD FOR THE USE OF PYRANOINDOLE DERIVATIVES TO TREAT INFECTION WITH HEPATITIS C VIRUS". Page 59. . Retrieved 2008/06/13.