Aristolactam BIII

Base Information

• Chemical Name: Aristolactam BIII
• CAS No.: 53948-10-0
• Molecular Formula: C18H15NO4
• Molecular Weight: 309.32
• Hs Code.: 2933990090
• Mol file: 53948-10-0.mol

Synonyms:3,4,6-trimethoxyaristolactame;aristolactam A II;Aristololactam B III;aristololactam A-II;Dibenz(cd,f)indol-4(5H)-one,2-hydroxy-1-methoxy;aristolactam BIII;

Chemical Property of Aristolactam BIII

Chemical Property:

• PSA: 60.28000
• LogP: 3.40410

Purity/Quality:

98%Min ^*data from raw suppliers

AristolactamBIII ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Aristolactam BIII

There total 7 articles about Aristolactam BIII which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-bromo-5,6-dimethoxyisoindolin-1-one (1042722-42-8) + (2-formyl-5-methoxyphenyl)boronic acid (40138-18-9) → aristololactam BIII (53948-10-0)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In ethanol; toluene; at 150 ℃; for 0.166667h; under 4500.45 - 6000.6 Torr; Microwave irradiation; Inert atmosphere;

DOI:10.1021/ol801291k

Reference yield: 83.0%

→ aristololactam BIII (53948-10-0)

Guidance literature:

Reference yield: 35.0%

(E)-N-(4'-methoxystyryl)-2-bromo-4,5-dimethoxybenzamide (128580-96-1) → aristololactam BIII (53948-10-0)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at 0 ℃;

DOI:10.1016/S0040-4039(00)76197-1

upstream raw materials:

(E)-N-(4'-methoxystyryl)-2-bromo-4,5-dimethoxybenzamide

2-bromo-4,5-dimethoxybenzoic acid

2-Bromo-4,5-dimethoxy-N-[2-(4-methoxy-phenyl)-ethyl]-benzamide

Acetic acid 2-(2-bromo-4,5-dimethoxy-benzoylamino)-1-(4-methoxy-phenyl)-ethyl ester

Refernces

• 1、 Choi, Young Lok,Kim, Joa Kyum,Choi, Sang-Un,Min, Yong-Ki,Bae, Myung-Ae,Kim, Bum Tae,Heo, Jung-Nyoung. "Synthesis of aristolactam analogues and evaluation of their antitumor activity". experimental part. p. 3036 - 3040. Retrieved 2010/02/28.
• 2、 Estevez, Juan C.,Estevez, Ramon J.,Castedo, Luis. "The Intramolecular Aryne Cycloaddition Approach to Aporphinoids. A New Total Synthesis of Aristolactams and Phenanthrene Alkaloids". . p. 10801 - 10810. Retrieved 2007/10/02.